Anti-PGA5 Antibody (CAB12951)
- SKU:
- CAB12951
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PGA5 Antibody |
| 抗体コード: | CAB12951 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 63-180 of human PGA5 (NP_055039.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, HT-29, 293T, Mouse brain, Mouse stomach, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 63-180 of human PGA5 (NP_055039.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VDEQ PLEN YLDM EYFG TIGI GTPA QDFT VVFD TGSS NLWV PSVY CSSL ACTN HNRF NPED SSTY QSTS ETVS ITYG TGSM TGIL GYDT VQVG GISD TNQI FGLS ETEP GSFL YYAP FD |
| 遺伝子ID: | 5222 |
| Uniprot: | P0DJD9 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 41kDa |
| 観察された分子量: | 42kDa |
| 同義語: | PGA5, Pg5 |
| バックグラウンド: | This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. |
| UniProt Protein Function: | PGA5: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. Belongs to the peptidase A1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.23.1; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q13 Molecular Function:aspartic-type endopeptidase activity; peptidase activity Biological Process: cellular protein metabolic process; protein catabolic process; proteolysis |
| NCBI Summary: | This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P0DJD9 |
| NCBI GenInfo Identifier: | 378522017 |
| NCBI Gene ID: | 5222 |
| NCBI Accession: | P0DJD9.1 |
| UniProt Secondary Accession: | P0DJD9,P00790, Q7M4R0, Q8N1E3, A8K749, B7ZW62, B7ZW75 |
| UniProt Related Accession: | P0DJD9 |
| Molecular Weight: | 41,993 Da |
| NCBI Full Name: | Pepsin A-5 |
| NCBI Synonym Full Names: | pepsinogen 5, group I (pepsinogen A) |
| NCBI Official Symbol: | PGA5 |
| NCBI Official Synonym Symbols: | Pg5 |
| NCBI Protein Information: | pepsin A-5 |
| UniProt Protein Name: | Pepsin A-5 |
| UniProt Synonym Protein Names: | Pepsinogen-5 |
| Protein Family: | Pepsin |
| UniProt Gene Name: | PGA5 |
| UniProt Entry Name: | PEPA5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PGA5 antibody (CAB12951) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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