Anti-PFKFB3 Antibody (CAB14764)
- SKU:
- CAB14764
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PFKFB3 Antibody |
| 抗体コード: | CAB14764 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PFKFB3 (NP_004557.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PFKFB3 (NP_004557.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MPLE LTQS RVQK IWVP VDHR PSLP RSCG PKLT NSPT VIVM VGLP ARGK TYIS KKLT RYLN WIGV PTKV FNVG EYRR EAVK QYSS YNFF RPDN EEAM KVRK QCAL AALR DVKS YLAK EGGQ IAVF DATN TTRE RRHM ILHF AKEN DFKA FFIE SVCD DPTV VASN IMEV KISS PDYK DCNS AEAM DDFM KRIS CYEA SYQP LDPD KCDR DL |
| 遺伝子ID: | 5209 |
| Uniprot: | Q16875 |
| セルラーロケーション: | |
| 計算された分子量: | 57kDa/58kDa/59kDa/60kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | PFKFB3, IPFK2, PFK2, iPFK-2 |
| バックグラウンド: | The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate (F2, 6BP), and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of F2, 6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PFKFB3: Synthesis and degradation of fructose 2,6-bisphosphate. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, other; Motility/polarity/chemotaxis; Carbohydrate Metabolism - fructose and mannose; EC 3.1.3.46; Phosphatase (non-protein); EC 2.7.1.105 Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: cytosol; nucleoplasm Molecular Function:6-phosphofructo-2-kinase activity |
| NCBI Summary: | The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] |
| UniProt Code: | Q16875 |
| NCBI GenInfo Identifier: | 3023733 |
| NCBI Gene ID: | 5209 |
| NCBI Accession: | Q16875.1 |
| UniProt Secondary Accession: | Q16875,O43622, O75902, Q5VX15, Q5VX18, Q5VX19, B7Z955 |
| UniProt Related Accession: | Q16875 |
| Molecular Weight: | 60,602 Da |
| NCBI Full Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
| NCBI Synonym Full Names: | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
| NCBI Official Symbol: | PFKFB3 |
| NCBI Official Synonym Symbols: | PFK2; IPFK2; iPFK-2 |
| NCBI Protein Information: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
| UniProt Protein Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
| UniProt Synonym Protein Names: | 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Renal carcinoma antigen NY-REN-56; iPFK-2Including the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46) |
| Protein Family: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase |
| UniProt Gene Name: | PFKFB3 |
| UniProt Entry Name: | F263_HUMAN |
 | Immunofluorescence analysis of U2OS cells using PFKFB3 antibody (CAB14764). Blue: DAPI for nuclear staining. |
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