Anti-PF4 Antibody (CAB17376)
- SKU:
- CAB17376
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-PF4 Antibody |
| 抗体コード: | CAB17376 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human PF4. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human PF4. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 5196 |
| Uniprot: | P02776 |
| セルラーロケーション: | |
| 計算された分子量: | 11kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | PF-4, CXCL4, SCYB4, PF4 |
| バックグラウンド: | This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. |
| UniProt Protein Function: | PF4: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Apoptosis; Secreted, signal peptide; Chemokine; Secreted Chromosomal Location of Human Ortholog: 4q12-q21 Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; CXCR3 chemokine receptor binding; chemokine activity Biological Process: negative regulation of cytolysis; platelet activation; leukocyte chemotaxis; cytokine and chemokine mediated signaling pathway; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; positive regulation of tumor necrosis factor production; negative regulation of megakaryocyte differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; platelet degranulation; negative regulation of MHC class II biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of macrophage differentiation; inflammatory response; blood coagulation |
| NCBI Summary: | This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P02776 |
| NCBI GenInfo Identifier: | 130304 |
| NCBI Gene ID: | 5196 |
| NCBI Accession: | P02776.2 |
| UniProt Secondary Accession: | P02776,Q53X61, Q9UC64, Q9UC65, |
| UniProt Related Accession: | P02776 |
| Molecular Weight: | 10,845 Da |
| NCBI Full Name: | Platelet factor 4 |
| NCBI Synonym Full Names: | platelet factor 4 |
| NCBI Official Symbol: | PF4 |
| NCBI Official Synonym Symbols: | PF-4; CXCL4; SCYB4 |
| NCBI Protein Information: | platelet factor 4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4 |
| UniProt Protein Name: | Platelet factor 4 |
| UniProt Synonym Protein Names: | C-X-C motif chemokine 4; Iroplact; Oncostatin-ACleaved into the following chain:Platelet factor 4, short form |
| Protein Family: | Platelet factor |
| UniProt Gene Name: | PF4 |
| UniProt Entry Name: | PLF4_HUMAN |