Anti-PES1 Antibody (CAB14506)
- SKU:
- CAB14506
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-PES1 Antibody |
抗体コード: | CAB14506 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PES1 (NP_055118.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | MCF7, HepG2, Jurkat |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PES1 (NP_055118.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MGGL EKKK YERG SATN YITR NKAR KKLQ LSLA DFRR LCIL KGIY PHEP KHKK KVNK GSTA ARTF YLIK DIRF LLHE PIVN KFRE YKVF VRKL RKAY GKSE WNTV ERLK DNKP NYKL DHII KERY PTFI DALR DLDD ALSM CFLF STFP RT |
遺伝子ID: | 23481 |
Uniprot: | O00541 |
セルラーロケーション: | Chromosome, Nucleus, nucleolus, nucleoplasm |
計算された分子量: | 67kDa/68kDa |
観察された分子量: | 68kDa |
同義語: | PES1, PES, NOP7 |
バックグラウンド: | This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. |
UniProt Protein Function: | PES1: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the pescadillo family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Translation; RNA-binding; Nucleolus Chromosomal Location of Human Ortholog: 22q12.1 Cellular Component: cytoplasm; membrane; nucleolus; nucleoplasm; nucleus Molecular Function:protein binding; RNA binding Biological Process: cell proliferation; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of cell cycle; ribosomal large subunit biogenesis and assembly; rRNA processing |
NCBI Summary: | This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011] |
UniProt Code: | O00541 |
NCBI GenInfo Identifier: | 21542165 |
NCBI Gene ID: | 23481 |
NCBI Accession: | O00541.1 |
UniProt Secondary Accession: | O00541,Q6IC29, |
UniProt Related Accession: | O00541 |
Molecular Weight: | 67,456 Da |
NCBI Full Name: | Pescadillo homolog |
NCBI Synonym Full Names: | pescadillo ribosomal biogenesis factor 1 |
NCBI Official Symbol: | PES1 |
NCBI Official Synonym Symbols: | PES |
NCBI Protein Information: | pescadillo homolog |
UniProt Protein Name: | Pescadillo homolog |
UniProt Gene Name: | PES1 |
UniProt Entry Name: | PESC_HUMAN |
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