Anti-PER1 Antibody (CAB8449)
- SKU:
- CAB8449
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-PER1 Antibody |
抗体コード: | CAB8449 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PER1 (NP_002607.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Jurkat, B cells, A-549, Mouse brain, Mouse testis, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PER1 (NP_002607.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSGP LEGA DGGG DPRP GESF CPGG VPSP GPPQ HRPC PGPS LADD TDAN SNGS SGNE SNGH ESRG ASQR SSHS SSSG NGKD SALL ETTE SSKS TNSQ SPSP PSSS IAYS LLSA SSEQ DNPS TSGC SSEQ SARA RTQK ELMT ALRE LKLR LPPE RRGK GRSG TLAT LQYA LACV KQVQ ANQE YYQQ WSLE EGEP CSMD MSTY |
遺伝子ID: | 5187 |
Uniprot: | O15534 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 91kDa/136kDa |
観察された分子量: | 160kDa |
同義語: | PER1, PER, RIGUI, hPER |
バックグラウンド: | This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. |
UniProt Protein Function: | PER1: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Can bind heme. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: cytoplasm Molecular Function:chromatin DNA binding; kinase binding; ubiquitin protein ligase binding Biological Process: circadian regulation of gene expression; circadian rhythm; entrainment of circadian clock; entrainment of circadian clock by photoperiod; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; regulation of hair cycle; regulation of sodium ion transport |
NCBI Summary: | This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014] |
UniProt Code: | O15534 |
NCBI GenInfo Identifier: | 218511752 |
NCBI Gene ID: | 5187 |
NCBI Accession: | O15534.2 |
UniProt Secondary Accession: | O15534,B2RPA8, B4DI49, D3DTR3, |
UniProt Related Accession: | O15534 |
Molecular Weight: | |
NCBI Full Name: | Period circadian protein homolog 1 |
NCBI Synonym Full Names: | period circadian clock 1 |
NCBI Official Symbol: | PER1 |
NCBI Official Synonym Symbols: | PER; hPER; RIGUI |
NCBI Protein Information: | period circadian protein homolog 1 |
UniProt Protein Name: | Period circadian protein homolog 1 |
UniProt Synonym Protein Names: | Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui |
Protein Family: | Protein |
UniProt Gene Name: | PER1 |
UniProt Entry Name: | PER1_HUMAN |
View AllClose