Anti-PDYN Antibody (CAB5830)
- SKU:
- CAB5830
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-PDYN Antibody |
抗体コード: | CAB5830 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-254 of human PDYN (NP_077722.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-251MG, Mouse liver, Mouse pancreas |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-254 of human PDYN (NP_077722.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | DCLS RCSL CAVK TQDG PKPI NPLI CSLQ CQAA LLPS EEWE RCQS FLSF FTPS TLGL NDKE DLGS KSVG EGPY SELA KLSG SFLK ELEK SKFL PSIS TKEN TLSK SLEE KLRG LSDG FREG AESE LMRD AQLN DGAM ETGT LYLA EEDP KEQV KRYG GFLR KYPK RSSE VAGE GDGD SMGH EDLY KRYG GFLR RIRP KLKW DNQK RYGG FLRR QFKV VTRS QEDP NAYS GELF DA |
遺伝子ID: | 5173 |
Uniprot: | P01213 |
セルラーロケーション: | Secreted |
計算された分子量: | 28kDa |
観察された分子量: | 28kDa |
同義語: | PDYN, ADCA, PENKB, SCA23 |
バックグラウンド: | The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. |
UniProt Protein Function: | PDYN: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. Belongs to the opioid neuropeptide precursor family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20p13 Cellular Component: plasma membrane; extracellular region Molecular Function:opioid peptide activity Biological Process: synaptic transmission; neuropeptide signaling pathway Disease: Spinocerebellar Ataxia 23 |
NCBI Summary: | The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010] |
UniProt Code: | P01213 |
NCBI GenInfo Identifier: | 127976 |
NCBI Gene ID: | 5173 |
NCBI Accession: | P01213.1 |
UniProt Related Accession: | P01213 |
Molecular Weight: | |
NCBI Full Name: | Proenkephalin-B |
NCBI Synonym Full Names: | prodynorphin |
NCBI Official Symbol: | PDYN |
NCBI Official Synonym Symbols: | ADCA; PENKB; SCA23 |
NCBI Protein Information: | proenkephalin-B |
UniProt Protein Name: | Proenkephalin-B |
UniProt Synonym Protein Names: | Beta-neoendorphin-dynorphin; PreprodynorphinCleaved into the following 9 chains:Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin; Big Dyn; Dynorphin A(1-17); Dyn-A17; Dynorphin A; Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; RimorphinAlternative name(s):Dynorphin B; Dyn-B; Dynorphin B(1-13) |
Protein Family: | Proenkephalin |
UniProt Gene Name: | PDYN |
UniProt Entry Name: | PDYN_HUMAN |
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