Anti-PDXP Antibody (CAB17455)
- SKU:
- CAB17455
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PDXP Antibody |
| 抗体コード: | CAB17455 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human PDXP (NP_064711.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Rat brain |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human PDXP (NP_064711.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VETA SGRQ ALVV GKPS PYMF ECIT ENFS IDPA RTLM VGDR LETD ILFG HRCG MTTV LTLT GVSR LEEA QAYL AAGQ HDLV PHYY VESI ADLT EGLE D |
| 遺伝子ID: | 57026 |
| Uniprot: | Q96GD0 |
| セルラーロケーション: | |
| 計算された分子量: | 32kDa |
| 観察された分子量: | 32KDa |
| 同義語: | CIN, PLP, dJ37E16.5, PDXP |
| バックグラウンド: | Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP. |
| UniProt Protein Function: | PDXP: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. Homodimer. Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. Belongs to the HAD-like hydrolase superfamily. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cofactor and Vitamin Metabolism - vitamin B6; EC 3.1.3.3; EC 3.1.3.74; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: actin cytoskeleton; cleavage furrow; cytosol; lamellipodium; midbody; plasma membrane Molecular Function:heat shock protein binding; magnesium ion binding; phosphoprotein phosphatase activity; protein binding; pyridoxal phosphatase activity Biological Process: actin rod formation; positive regulation of actin filament depolymerization; protein amino acid dephosphorylation; pyridoxal phosphate catabolic process; regulation of cytokinesis; regulation of mitosis |
| NCBI Summary: | Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96GD0 |
| NCBI GenInfo Identifier: | 10092677 |
| NCBI Gene ID: | 57026 |
| NCBI Accession: | NP_064711.1 |
| UniProt Secondary Accession: | Q96GD0,Q9UGY2, |
| UniProt Related Accession: | Q96GD0 |
| Molecular Weight: | 33.7 kDa |
| NCBI Full Name: | pyridoxal phosphate phosphatase |
| NCBI Synonym Full Names: | pyridoxal phosphatase |
| NCBI Official Symbol: | PDXP |
| NCBI Official Synonym Symbols: | CIN; PLP; dJ37E16.5 |
| NCBI Protein Information: | pyridoxal phosphate phosphatase |
| UniProt Protein Name: | Pyridoxal phosphate phosphatase |
| UniProt Synonym Protein Names: | Chronophin |
| Protein Family: | Pyridoxal phosphate phosphatase |
| UniProt Gene Name: | PDXP |
 | Western blot analysis of extracts of various cell lines, using PDXP Polyclonal Antibody (CAB17455) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded Mouse kidney using PDXP Rabbit pAb (CAB17455) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat lung using PDXP Rabbit pAb (CAB17455) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Human colon using PDXP Rabbit pAb (CAB17455) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of L929 cells using PDXP Rabbit pAb (CAB17455) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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