Anti-PDIA6 Antibody (CAB4260)
- SKU:
- CAB4260
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PDIA6 Antibody |
| 抗体コード: | CAB4260 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human PDIA6 |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, HepG2, Mouse liver, Rat liver |
| 免疫原: | A synthesized peptide derived from human PDIA6 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10130 |
| Uniprot: | Q15084 |
| セルラーロケーション: | |
| 計算された分子量: | 48kDa |
| 観察された分子量: | 54KDa |
| 同義語: | ERP5, P5, TXNDC7 |
| バックグラウンド: | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] |
| UniProt Protein Function: | PDIA6: May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 5.3.4.1; Isomerase Chromosomal Location of Human Ortholog: 2p25.1 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; endoplasmic reticulum; melanosome; plasma membrane; ER-Golgi intermediate compartment Molecular Function:protein binding; protein disulfide isomerase activity Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; protein folding; unfolded protein response; cell redox homeostasis; apoptotic cell clearance |
| NCBI Summary: | Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q15084 |
| NCBI GenInfo Identifier: | 2501205 |
| NCBI Gene ID: | 10130 |
| NCBI Accession: | Q15084.1 |
| UniProt Secondary Accession: | Q15084,Q53RC7, Q6ZSH5, Q99778, B3KY95, B5MCQ5, B7Z254 B7Z4M8, F8WA83, |
| UniProt Related Accession: | Q15084 |
| Molecular Weight: | 440 |
| NCBI Full Name: | Protein disulfide-isomerase A6 |
| NCBI Synonym Full Names: | protein disulfide isomerase family A, member 6 |
| NCBI Official Symbol: | PDIA6 |
| NCBI Official Synonym Symbols: | P5; ERP5; TXNDC7 |
| NCBI Protein Information: | protein disulfide-isomerase A6; ER protein 5; protein disulfide isomerase P5; endoplasmic reticulum protein 5; thioredoxin domain-containing protein 7; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; thioredoxin doma |
| UniProt Protein Name: | Protein disulfide-isomerase A6 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7 |
| Protein Family: | Protein disulfide-isomerase |
| UniProt Gene Name: | PDIA6 |
| UniProt Entry Name: | PDIA6_HUMAN |
 | Western blot - PDIA6 Rabbit mAb (CAB4260) |
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