Anti-PDIA6 Antibody (CAB18092)[KO Validated]
![Anti-PDIA6 Antibody (CAB18092)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/16185/16064/anti-pdia6-antibody-cab18092ko-validated__58506__24027.1645803186.jpg?c=1 "Anti-PDIA6 Antibody (CAB18092)[KO Validated]")
- SKU:
- CAB18092
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
![Anti-PDIA6 Antibody (CAB18092)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/16185/16064/anti-pdia6-antibody-cab18092ko-validated__58506__24027.1645803186.jpg?c=1&imbypass=on "Anti-PDIA6 Antibody (CAB18092)[KO Validated]")
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Description
| 抗体名: | Anti-PDIA6 Antibody [KO Validated] |
| 抗体コード: | CAB18092 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human PDIA6 (NP_005733.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human PDIA6 (NP_005733.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LYSS SDDV IELT PSNF NREV IQSD SLWL VEFY APWC GHCQ RLTP EWKK AATA LKDV VKVG AVDA DKHH SLGG QYGV QGFP TIKI FGSN KNRP EDYQ GGRT GEAI VDAA LSAL RQLV KDRL GGRS GGYS SGKQ GRSD SSSK KDVI ELTD DSFD KNVL DSED VWMV EFYA PWCG HCKN LEPE WAAA ASEV KEQT KGKV KLAA VDAT VNQV LASR YGIR GFPT IKIF QKGE SPVD YDGG RTRS DIVS RALD LFSD NAPP PELL EIIN EDIA KRTC EEHQ LCVV A |
| 遺伝子ID: | 10130 |
| Uniprot: | Q15084 |
| セルラーロケーション: | Cell membrane, Endoplasmic reticulum lumen, Melanosome |
| 計算された分子量: | 47kDa/48kDa/53kDa |
| 観察された分子量: | 48kDa |
![Anti-PDIA6 Antibody [KO Validated] (CAB18092)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/t/206/A18092_1__71175.jpg) | Western blot analysis of extracts from normal (control) and PDIA6 knockout (KO) 293T cells, using PDIA6 antibody (CAB18092) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | PDIA6, ERP5, P5, TXNDC7 |
| バックグラウンド: | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | PDIA6: May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 5.3.4.1; Isomerase Chromosomal Location of Human Ortholog: 2p25.1 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; endoplasmic reticulum; melanosome; plasma membrane; ER-Golgi intermediate compartment Molecular Function:protein binding; protein disulfide isomerase activity Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; protein folding; unfolded protein response; cell redox homeostasis; apoptotic cell clearance |
| NCBI Summary: | Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q15084 |
| NCBI GenInfo Identifier: | 2501205 |
| NCBI Gene ID: | 10130 |
| NCBI Accession: | Q15084.1 |
| UniProt Secondary Accession: | Q15084,Q53RC7, Q6ZSH5, Q99778, B3KY95, B5MCQ5, B7Z254 B7Z4M8, F8WA83, |
| UniProt Related Accession: | Q15084 |
| Molecular Weight: | 440 |
| NCBI Full Name: | Protein disulfide-isomerase A6 |
| NCBI Synonym Full Names: | protein disulfide isomerase family A, member 6 |
| NCBI Official Symbol: | PDIA6 |
| NCBI Official Synonym Symbols: | P5; ERP5; TXNDC7 |
| NCBI Protein Information: | protein disulfide-isomerase A6; ER protein 5; protein disulfide isomerase P5; endoplasmic reticulum protein 5; thioredoxin domain-containing protein 7; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; thioredoxin doma |
| UniProt Protein Name: | Protein disulfide-isomerase A6 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7 |
| Protein Family: | Protein disulfide-isomerase |
| UniProt Gene Name: | PDIA6 |
| UniProt Entry Name: | PDIA6_HUMAN |