Anti-PDE8A Antibody (CAB12187)
- SKU:
- CAB12187
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PDE8A Antibody |
| 抗体コード: | CAB12187 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human PDE8A (NP_002596.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse testis, Mouse eye, Mouse liver, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human PDE8A (NP_002596.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGCA PSIH ISER LVAE DAPS PAAP PLSS GGPR LPQG QKTA ALPR TRGA GLLE SELR DGSG KKVA VADV QFGP MRFH QDQL QVLL VFTK EDNQ CNGF CRAC EKAG FKCT VTKE AQAV LACF |
| 遺伝子ID: | 5151 |
| Uniprot: | O60658 |
| セルラーロケーション: | |
| 計算された分子量: | 25kDa/29kDa/86kDa/88kDa/93kDa |
| 観察された分子量: | 93kDa |
| 同義語: | PDE8A, HsT19550 |
| バックグラウンド: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PDE8A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Chromosomal Location of Human Ortholog: 15q25.3 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity; kinase binding Biological Process: positive regulation of protein amino acid phosphorylation |
| NCBI Summary: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | O60658 |
| NCBI GenInfo Identifier: | 23503044 |
| NCBI Gene ID: | 5151 |
| NCBI Accession: | O60658.2 |
| UniProt Secondary Accession: | O60658,Q6P9H3, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q96T71 Q9UMB7, Q9UMC3, B3KXE6, H0YMZ7, |
| UniProt Related Accession: | O60658 |
| Molecular Weight: | 93kDa |
| NCBI Full Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
| NCBI Synonym Full Names: | phosphodiesterase 8A |
| NCBI Official Symbol: | PDE8A |
| NCBI Official Synonym Symbols: | HsT19550 |
| NCBI Protein Information: | high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
| UniProt Protein Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
| Protein Family: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE8A |
 | Western blot analysis of extracts of various cell lines, using PDE8A antibody (CAB12187) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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