Anti-PDE7B Antibody (CAB12134)
- SKU:
- CAB12134
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PDE7B Antibody |
| 抗体コード: | CAB12134 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 341-450 of human PDE7B (NP_061818.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Mouse kidney, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 341-450 of human PDE7B (NP_061818.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VCEE FYRQ GELE QKFE LEIS PLCN QQKD SIPS IQIG FMSY IVEP LFRE WAHF TGNS TLSE NMLG HLAH NKAQ WKSL LPRQ HRSR GSSG SGPD HDHA GQGT ESEE QEGD SP |
| 遺伝子ID: | 27115 |
| Uniprot: | Q9NP56 |
| セルラーロケーション: | |
| 計算された分子量: | 51kDa |
| 観察された分子量: | 52kDa |
| 同義語: | PDE7B, bA472E5.1 |
| バックグラウンド: | The 3', 5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3', 5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. |
| UniProt Protein Function: | PDE7B: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. |
| UniProt Protein Details: | Protein type:EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Chromosomal Location of Human Ortholog: 6q23.3 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity Biological Process: synaptic transmission |
| NCBI Summary: | The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009] |
| UniProt Code: | Q9NP56 |
| NCBI GenInfo Identifier: | 13626185 |
| NCBI Gene ID: | 27115 |
| NCBI Accession: | Q9NP56.1 |
| UniProt Secondary Accession: | Q9NP56,Q5W154, |
| UniProt Related Accession: | Q9NP56 |
| Molecular Weight: | 52kDa |
| NCBI Full Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
| NCBI Synonym Full Names: | phosphodiesterase 7B |
| NCBI Official Symbol: | PDE7B |
| NCBI Official Synonym Symbols: | bA472E5.1 |
| NCBI Protein Information: | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
| UniProt Protein Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
| Protein Family: | cAMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE7B |
 | Western blot analysis of extracts of various cell lines, using PDE7B antibody (CAB12134) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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