Anti-PDE4B Antibody (CAB10196)
- SKU:
- CAB10196
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PDE4B Antibody |
| 抗体コード: | CAB10196 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human PDE4B (NP_002591.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:3000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-87MG, A-549, HL-60, Mouse brain, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human PDE4B (NP_002591.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKKS RSVM TVMA DDNV KDYF ECSL SKSY SSSS NTLG IDLW RGRR CCSG NLQL PPLS QRQS ERAR TPEG DGIS RPTT LPLT TLPS IAIT TVSQ ECFD VENG PSPG RSPL DPQA SSSA GLVL HATF PGHS QR |
| 遺伝子ID: | 5142 |
| Uniprot: | Q07343 |
| セルラーロケーション: | |
| 計算された分子量: | 57kDa/64kDa/82kDa/83kDa |
| 観察された分子量: | 83kDa |
| 同義語: | PDE4B, DPDE4, PDEIVB |
| バックグラウンド: | This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. |
| NCBI Summary: | This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q07343 |
| NCBI GenInfo Identifier: | 729163 |
| NCBI Gene ID: | 5142 |
| NCBI Accession: | Q07343.1 |
| UniProt Secondary Accession: | Q07343,O15443, Q13945, Q5TEK4, Q5TEK5, Q5TEK6, A5YW33 |
| UniProt Related Accession: | Q07343 |
| Molecular Weight: | 57,709 Da |
| NCBI Full Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
| NCBI Synonym Full Names: | phosphodiesterase 4B |
| NCBI Official Symbol: | PDE4B |
| NCBI Official Synonym Symbols: | DPDE4; PDEIVB |
| NCBI Protein Information: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
| UniProt Protein Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
| UniProt Synonym Protein Names: | DPDE4; PDE32 |
| Protein Family: | cAMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE4B |
| UniProt Entry Name: | PDE4B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PDE4B antibody (CAB10196) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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