Anti-PDE1C Antibody (CAB15078)
- SKU:
- CAB15078
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PDE1C Antibody |
| 抗体コード: | CAB15078 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 435-634 of human PDE1C (NP_001177985.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, mouse heart, mouse brain, mouse testis, rat heart, rat brain, rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 435-634 of human PDE1C (NP_001177985.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VEPT FTVL TDMT EKIV SPLI DETS QTGG TGQR RSSL NSIS SSDA KRSG VKTS GSEG SAPI NNSV ISVD YKSF KATW TEVV HINR ERWR AKVP KEEK AKKE AEEK ARLA AEEQ QKEM EAKS QAEE GASG KAEK KTSG ETKN QVNG TRAN KSDN PRGK NSKA EKSS GEQQ QNGD FKDG KNKT DKKD HSNI GNDS KKTD DSQE |
| 遺伝子ID: | 5137 |
| Uniprot: | Q14123 |
| セルラーロケーション: | |
| 計算された分子量: | 72kDa/80kDa/86kDa |
| 観察された分子量: | 81kDa |
| 同義語: | PDE1C, Hcam3, cam-PDE 1C, hCam-3, cam-PDE1C |
| バックグラウンド: | This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. |
| UniProt Protein Function: | PDE1C: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.17 Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: cytosol Molecular Function:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity |
| NCBI Summary: | This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q14123 |
| NCBI GenInfo Identifier: | 2499445 |
| NCBI Gene ID: | 5137 |
| NCBI Accession: | Q14123.1 |
| UniProt Secondary Accession: | Q14123,Q14124, Q8NB10, B3KPC6, E9PE92, |
| UniProt Related Accession: | Q14123 |
| Molecular Weight: | 86,896 Da |
| NCBI Full Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
| NCBI Synonym Full Names: | phosphodiesterase 1C |
| NCBI Official Symbol: | PDE1C |
| NCBI Official Synonym Symbols: | Hcam3; hCam-3; cam-PDE 1C |
| NCBI Protein Information: | calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
| UniProt Protein Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
| UniProt Synonym Protein Names: | hCam-3 |
| Protein Family: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase |
| UniProt Gene Name: | PDE1C |
| UniProt Entry Name: | PDE1C_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PDE1C antibody (CAB15078) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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