Anti-PDE12 Antibody (CAB17270)
- SKU:
- CAB17270
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-PDE12 Antibody |
| 抗体コード: | CAB17270 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse thymus, Rat thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AVEK LSRA EAGS QTAA GAME RAVV RCVP SEPK LSLS FALA DGSH KNMQ RDQS EPLG RVLS RIAT NALK GHAK AAAA KKSR KSRP NASG GAAC SGPG PEPA VFCE PVVK LYYR EEAV AEDV LNVD AWQD GAVL QIGD VKYK VERN PPAF TELQ LPRY IMAG FPVC PKLS LEFG DPAS SLFR WYKE AKPG AAEP EVGV PSSL SPSS PSSS WTET DVEE RVYT PSNA DIGL RLKL HCTP GDGQ RFGH SREL ESVC VVEA GPGT CTFD HRHL YTKK VTED ALIR TVSY |
| 遺伝子ID: | 201626 |
| Uniprot: | Q6L8Q7 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 67kDa |
 | Western blot - PDE12 Rabbit pAb (CAB17270) |
| 同義語: | PDE12, 2-PDE |
| バックグラウンド: |
| UniProt Protein Function: | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. |
| UniProt Code: | Q6L8Q7 |
| NCBI GenInfo Identifier: | 189027129 |
| NCBI Gene ID: | 201626 |
| NCBI Accession: | NP_808881.3 |
| UniProt Related Accession: | Q6L8Q7 |
| Molecular Weight: | 51kDa |
| NCBI Full Name: | 2',5'-phosphodiesterase 12 isoform 1 |
| NCBI Synonym Full Names: | phosphodiesterase 12 |
| NCBI Official Symbol: | PDE12 |
| NCBI Official Synonym Symbols: | 2-PDE; 2'-PDE |
| NCBI Protein Information: | 2',5'-phosphodiesterase 12 |
| UniProt Protein Name: | 2',5'-phosphodiesterase 12 |
| UniProt Synonym Protein Names: | Mitochondrial deadenylase (EC:3.1.13.4) |
| Protein Family: | 2',5'-phosphodiesterase |
| UniProt Gene Name: | PDE12 |