Anti-PDE11A Antibody (CAB16121)
- SKU:
- CAB16121
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-PDE11A Antibody |
| 抗体コード: | CAB16121 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 712-933 of human PDE11A (NP_058649.3). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Mouse testis, Mouse liver, Rat brain, Rat testis, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 712-933 of human PDE11A (NP_058649.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NNAF QAKS GSAL AQLY GTSA TLEH HHFN HAVM ILQS EGHN IFAN LSSK EYSD LMQL LKQS ILAT DLTL YFER RTEF FELV SKGE YDWN IKNH RDIF RSML MTAC DLGA VTKP WEIS RQVA ELVT SEFF EQGD RERL ELKL TPSA IFDR NRKD ELPR LQLE WIDS ICMP LYQA LVKV NVKL KPML DSVA TNRS KWEE LHQK RLLA STAS SSPA SVMV AKED RN |
| 遺伝子ID: | 50940 |
| Uniprot: | Q9HCR9 |
| セルラーロケーション: | Cytoplasm, cytosol |
| 計算された分子量: | 55kDa/65kDa/78kDa/104kDa |
| 観察された分子量: | 105kDa |
| 同義語: | PDE11A, PPNAD2 |
| バックグラウンド: | The 3', 5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3', 5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PDE11A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. Defects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2). Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to Cushing syndrome. Belongs to the cyclic nucleotide phosphodiesterase family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.4.17; Phosphodiesterase; Nucleotide Metabolism - purine; Mitochondrial; EC 3.1.4.35 Chromosomal Location of Human Ortholog: 2q31.2 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Disease: Pigmented Nodular Adrenocortical Disease, Primary, 2 |
| NCBI Summary: | The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HCR9 |
| NCBI GenInfo Identifier: | 296439264 |
| NCBI Gene ID: | 50940 |
| NCBI Accession: | Q9HCR9.2 |
| UniProt Secondary Accession: | Q9HCR9,Q14CD1, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45 |
| UniProt Related Accession: | Q9HCR9 |
| Molecular Weight: | 55,700 Da |
| NCBI Full Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
| NCBI Synonym Full Names: | phosphodiesterase 11A |
| NCBI Official Symbol: | PDE11A |
| NCBI Official Synonym Symbols: | PPNAD2 |
| NCBI Protein Information: | dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
| UniProt Protein Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
| UniProt Synonym Protein Names: | cAMP and cGMP phosphodiesterase 11A |
| Protein Family: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase |
| UniProt Gene Name: | PDE11A |
| UniProt Entry Name: | PDE11_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PDE11A Rabbit pAb (CAB16121) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunofluorescence analysis of L929 cells using PDE11A antibody (CAB16121) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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