Anti-PDCD2 Antibody (CAB15299)

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SKU:
CAB15299
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
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Description

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抗体名:Anti-PDCD2 Antibody
抗体コード:CAB15299
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-344 of human PDCD2 (NP_002589.2).
申し込み:WB
推奨希釈:WB 1:200 - 1:2000
反応性:Human
ポジティブサンプル:293T, HeLa
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-344 of human PDCD2 (NP_002589.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MAAA GARP VELG FAES APAW RLRS EQFP SKVG GRPA WLGA AGLP GPQA LACE LCGR PLSF LLQV YAPL PGRP DAFH RCIF LFCC REQP CCAG LRVF RNQL PRKN DFYS YEPP SENP PPET GESV CLQL KSGA HLCR VCGC LGPK TCSR CHKA YYCS KEHQ TLDW RLGH KQAC AQPD HLDH IIPD HNFL FPEF EIVI ETED EIMP EVVE KEDY SEII GSMG EALE EELD SMAK HESR EDKI FQKF KTQI ALEP EQIL RYGR GIAP IWIS GENI PQEK DIPD CPCG AKRI LEFQ VMPQ LLNY LKAD RLGK SIDW GILA VFTC AESC SLGT GYTE EFVW KQDV TDTP
遺伝子ID:5134
Uniprot:Q16342
セルラーロケーション:Nucleus
計算された分子量:21kDa/22kDa/25kDa/35kDa/38kDa
観察された分子量:38kDa
同義語:PDCD2, RP8, ZMYND7
バックグラウンド:This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12.
UniProt Protein Function:PDCD2: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding; enzyme binding; DNA binding; metal ion binding

Biological Process: caspase activation; apoptosis; positive regulation of apoptosis

NCBI Summary:This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]
UniProt Code:Q16342
NCBI GenInfo Identifier:14249983
NCBI Gene ID:5134
NCBI Accession:AAH08378.1
UniProt Secondary Accession:Q16342,Q58HM9, Q58HN0, Q9UH12, E9PCU7, F5GYS7,
UniProt Related Accession:Q16342
Molecular Weight:21,299 Da
NCBI Full Name:Programmed cell death 2
NCBI Synonym Full Names:programmed cell death 2
NCBI Official Symbol:PDCD2  
NCBI Official Synonym Symbols:RP8; ZMYND7  
NCBI Protein Information:programmed cell death protein 2; zinc finger protein Rp-8; zinc finger MYND domain-containing protein 7
UniProt Protein Name:Programmed cell death protein 2
UniProt Synonym Protein Names:Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8
Protein Family:Programmed cell death protein
UniProt Gene Name:PDCD2  
UniProt Entry Name:PDCD2_HUMAN
Anti-PDCD2 Antibody (CAB15299)Western blot analysis of extracts of various cell lines, using PDCD2 antibody (CAB15299) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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