Anti-PCSK4 Antibody (CAB18433)
- SKU:
- CAB18433
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-PCSK4 Antibody |
| 抗体コード: | CAB18433 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human PCSK4. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human PCSK4. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 54760 |
| Uniprot: | Q6UW60 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | PC4, SPC5, PCSK4 |
| バックグラウンド: |
| UniProt Protein Function: | PCSK4: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex. Belongs to the peptidase S8 family. Furin subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Protease; EC 3.4.21.-; Cell development/differentiation Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: integral to membrane; acrosomal membrane Molecular Function:serine-type endopeptidase activity Biological Process: binding of sperm to zona pellucida; acrosome reaction; proteolysis; sperm capacitation |
| NCBI Summary: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II. [provided by RefSeq, Jan 2014] |
| UniProt Code: | Q6UW60 |
| NCBI GenInfo Identifier: | 296439263 |
| NCBI Gene ID: | 54760 |
| NCBI Accession: | Q6UW60.2 |
| UniProt Secondary Accession: | Q6UW60,Q8IY88, Q9UF79, |
| UniProt Related Accession: | Q6UW60 |
| Molecular Weight: | 26,118 Da |
| NCBI Full Name: | Proprotein convertase subtilisin/kexin type 4 |
| NCBI Synonym Full Names: | proprotein convertase subtilisin/kexin type 4 |
| NCBI Official Symbol: | PCSK4 |
| NCBI Official Synonym Symbols: | PC4; SPC5 |
| NCBI Protein Information: | proprotein convertase subtilisin/kexin type 4; PCSK4 |
| UniProt Protein Name: | Proprotein convertase subtilisin/kexin type 4 |
| UniProt Synonym Protein Names: | Proprotein convertase 4; PC4 |
| Protein Family: | Proprotein convertase subtilisin/kexin |
| UniProt Gene Name: | PCSK4 |
| UniProt Entry Name: | PCSK4_HUMAN |