Anti-PCSK1 Antibody (CAB12237)
- SKU:
- CAB12237
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PCSK1 Antibody |
| 抗体コード: | CAB12237 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 604-753 of human PCSK1 (NP_000430.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 604-753 of human PCSK1 (NP_000430.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PRVY TSYN TVQN DRRG VEKM VDPG EEQP TQEN PKEN TLVS KSPS SSSV GGRR DELE EGAP SQAM LRLL QSAF SKNS PPKQ SPKK SPSA KLNI PYEN FYEA LEKL NKPS QLKD SEDS LYND YVDV FYNT KPYK HRDD RLLQ ALVD ILNE EN |
| 遺伝子ID: | 5122 |
| Uniprot: | P29120 |
| セルラーロケーション: | Cytoplasmic vesicle, secretory vesicle |
| 計算された分子量: | 79kDa/84kDa |
| 観察された分子量: | 84kDa |
| 同義語: | PCSK1, BMIQ12, NEC1, PC1, PC3, SPC3 |
| バックグラウンド: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene |
| UniProt Protein Function: | PCSK1: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily. |
| UniProt Protein Details: | Protein type:EC 3.4.21.93; Protease Chromosomal Location of Human Ortholog: 5q15-q21 Cellular Component: Golgi apparatus; extracellular space; transport vesicle Molecular Function:serine-type endopeptidase activity Biological Process: cellular protein metabolic process; cell-cell signaling; metabolic process; peptide hormone processing; proteolysis; regulation of insulin secretion; peptide biosynthetic process Disease: Proprotein Convertase 1/3 Deficiency; Body Mass Index Quantitative Trait Locus 12 |
| NCBI Summary: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014] |
| UniProt Code: | P29120 |
| NCBI GenInfo Identifier: | 116242674 |
| NCBI Gene ID: | 5122 |
| NCBI Accession: | P29120.2 |
| UniProt Related Accession: | P29120 |
| Molecular Weight: | |
| NCBI Full Name: | Neuroendocrine convertase 1 |
| NCBI Synonym Full Names: | proprotein convertase subtilisin/kexin type 1 |
| NCBI Official Symbol: | PCSK1 |
| NCBI Official Synonym Symbols: | PC1; PC3; NEC1; SPC3; BMIQ12 |
| NCBI Protein Information: | neuroendocrine convertase 1 |
| UniProt Protein Name: | Neuroendocrine convertase 1 |
| UniProt Synonym Protein Names: | Prohormone convertase 1; Proprotein convertase 1; PC1 |
| Protein Family: | Nectarin |
| UniProt Gene Name: | PCSK1 |
| UniProt Entry Name: | NEC1_HUMAN |
 | Western blot analysis of extracts of rat brain, using PCSK1 antibody (CAB12237) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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