Anti-PCDHGC3 Antibody (CAB10235)
- SKU:
- CAB10235
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PCDHGC3 Antibody |
| 抗体コード: | CAB10235 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-270 of human PCDHGC3 (NP_002579.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2, MCF7, SW620, Mouse liver, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-270 of human PCDHGC3 (NP_002579.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VIHY EIPE EREK GFAV GNVV ANLG LDLG SLSA RRFR VVSG ASRR FFEV NRET GEMF VNDR LDRE ELCG TLPS CTVT LELV VENP LELF SVEV VIQD INDN NPAF PTQE MKLE ISEA VAPG TRFP LESA HDPD VGSN SLQT YELS RNEY FALR VQTR EDST KYAE LVLE RALD RERE PSLQ LVLT ALDG GTPA LSAS LPIH IKVL DAND NAPV FNQS LYRA RVLE DAPS GTRV VQVL ATD |
| 遺伝子ID: | 5098 |
| Uniprot: | Q9UN70 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 94kDa/101kDa |
| 観察された分子量: | 140kDa |
| 同義語: | PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2 |
| バックグラウンド: | This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. |
| UniProt Protein Function: | PCDHGC3: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: integral to plasma membrane Biological Process: cell adhesion; cell-cell signaling; nervous system development |
| NCBI Summary: | This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UN70 |
| NCBI GenInfo Identifier: | 37999813 |
| NCBI Gene ID: | 5098 |
| NCBI Accession: | Q9UN70.1 |
| UniProt Secondary Accession: | Q9UN70,O60622, Q08192, Q9Y5C4, |
| UniProt Related Accession: | Q9UN70 |
| Molecular Weight: | 101kDa |
| NCBI Full Name: | Protocadherin gamma-C3 |
| NCBI Synonym Full Names: | protocadherin gamma subfamily C, 3 |
| NCBI Official Symbol: | PCDHGC3 |
| NCBI Official Synonym Symbols: | PC43; PCDH2; PCDH-GAMMA-C3 |
| NCBI Protein Information: | protocadherin gamma-C3 |
| UniProt Protein Name: | Protocadherin gamma-C3 |
| UniProt Synonym Protein Names: | Protocadherin-2; Protocadherin-43; PC-43 |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHGC3 |
 | Western blot analysis of extracts of various cell lines, using PCDHGC3 antibody (CAB10235) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
View AllClose