| バックグラウンド: | This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. |
| UniProt Protein Function: | PCDHGA1: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Calcium-binding; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 5q31 |
| NCBI Summary: | This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5H4 |
| NCBI GenInfo Identifier: | 37999844 |
| NCBI Gene ID: | 56114 |
| NCBI Accession: | Q9Y5H4.1 |
| UniProt Secondary Accession: | Q9Y5H4,Q2M273, Q9Y5D6, |
| UniProt Related Accession: | Q9Y5H4 |
| Molecular Weight: | 90,160 Da |
| NCBI Full Name: | Protocadherin gamma-A1 |
| NCBI Synonym Full Names: | protocadherin gamma subfamily A, 1 |
| NCBI Official Symbol: | PCDHGA1 |
| NCBI Official Synonym Symbols: | PCDH-GAMMA-A1 |
| NCBI Protein Information: | protocadherin gamma-A1 |
| UniProt Protein Name: | Protocadherin gamma-A1 |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHGA1 |
| UniProt Entry Name: | PCDG1_HUMAN |
