| バックグラウンド: | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. |
| UniProt Protein Function: | PCDHA12: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 5q31 |
| NCBI Summary: | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UN75 |
| NCBI GenInfo Identifier: | 13878425 |
| NCBI Gene ID: | 56137 |
| NCBI Accession: | Q9UN75.1 |
| UniProt Secondary Accession: | Q9UN75,O75278, Q2M1N8, |
| UniProt Related Accession: | Q9UN75 |
| Molecular Weight: | 85,581 Da |
| NCBI Full Name: | Protocadherin alpha-12 |
| NCBI Synonym Full Names: | protocadherin alpha 12 |
| NCBI Official Symbol: | PCDHA12 |
| NCBI Official Synonym Symbols: | PCDH-ALPHA12 |
| NCBI Protein Information: | protocadherin alpha-12 |
| UniProt Protein Name: | Protocadherin alpha-12 |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHA12 |
| UniProt Entry Name: | PCDAC_HUMAN |
