Anti-PCDHA10 Antibody (CAB17185)
- SKU:
- CAB17185
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PCDHA10 Antibody |
| 抗体コード: | CAB17185 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human PCDHA10 (NP_114066.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human PCDHA10 (NP_114066.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PRFS VTEQ KLSI PESR LLDS RFPL EGAS DADV GENA LLTY KLSP NEYF VLDI INKK DKDK FPVL VLRK LLDR EENP QLKL L |
| 遺伝子ID: | 56139 |
| Uniprot: | Q9Y5I2 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | PCDHA10, CNR8, CNRN8, CNRS8, CRNR8, PCDH-ALPHA10 |
| バックグラウンド: | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. |
| UniProt Protein Function: | PCDHA10: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 5q31 Cellular Component: integral to plasma membrane Biological Process: cell adhesion; nervous system development |
| NCBI Summary: | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5I2 |
| NCBI GenInfo Identifier: | 13878433 |
| NCBI Gene ID: | 56139 |
| NCBI Accession: | Q9Y5I2.1 |
| UniProt Secondary Accession: | Q9Y5I2,O75280, Q9NRU2, A1L493, |
| UniProt Related Accession: | Q9Y5I2 |
| Molecular Weight: | 92,185 Da |
| NCBI Full Name: | Protocadherin alpha-10 |
| NCBI Synonym Full Names: | protocadherin alpha 10 |
| NCBI Official Symbol: | PCDHA10 |
| NCBI Official Synonym Symbols: | CNR8; CNRN8; CNRS8; CRNR8; PCDH-ALPHA10 |
| NCBI Protein Information: | protocadherin alpha-10 |
| UniProt Protein Name: | Protocadherin alpha-10 |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHA10 |
| UniProt Entry Name: | PCDAA_HUMAN |
 | Western blot analysis of extracts of U-87MG cells, using PCDHA10 antibody (CAB17185) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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