| バックグラウンド: | The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. |
| UniProt Protein Function: | PBXIP1: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 1q21.3 Molecular Function:protein binding |
| NCBI Summary: | The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q96AQ6 |
| NCBI GenInfo Identifier: | 74751749 |
| NCBI Gene ID: | 57326 |
| NCBI Accession: | Q96AQ6.1 |
| UniProt Secondary Accession: | Q96AQ6,Q5T174, Q5T176, Q9H8X6, Q9HA02, Q9HD85, |
| UniProt Related Accession: | Q96AQ6 |
| Molecular Weight: | 72,920 Da |
| NCBI Full Name: | Pre-B-cell leukemia transcription factor-interacting protein 1 |
| NCBI Synonym Full Names: | PBX homeobox interacting protein 1 |
| NCBI Official Symbol: | PBXIP1 |
| NCBI Official Synonym Symbols: | HPIP |
| NCBI Protein Information: | pre-B-cell leukemia transcription factor-interacting protein 1 |
| UniProt Protein Name: | Pre-B-cell leukemia transcription factor-interacting protein 1 |
| UniProt Synonym Protein Names: | Hematopoietic PBX-interacting protein |
| Protein Family: | Pre-B-cell leukemia transcription factor-interacting protein |
| UniProt Gene Name: | PBXIP1 |
| UniProt Entry Name: | PBIP1_HUMAN |
