Anti-PAX3 Antibody (CAB13930)
- SKU:
- CAB13930
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-PAX3 Antibody |
| 抗体コード: | CAB13930 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human PAX3 (NP_039230.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human PAX3 (NP_039230.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTTL AGAV PRMM RPGP GQNY PRSG FPLE VSTP LGQG RVNQ LGGV FING RPLP NHIR HKIV EMAH HGIR PCVI SRQL RVSH GCVS KILC RYQE TGSI RPGA IGGS KPKQ VTTP DVEK KIEE YKRE NPGM FSWE IRDK LLKD AVCD RNTV PSVS SISR ILRS KFGK GEEE EADL ERKE AEES EKKA KHSI DGIL SERG KALV SGVS SH |
| 遺伝子ID: | 5077 |
| Uniprot: | P23760 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 22kDa/24kDa/44kDa/45kDa/52kDa/53kDa/55kDa |
| 観察された分子量: | 65kDa |
| 同義語: | PAX3, CDHS, HUP2, WS1, WS3 |
| バックグラウンド: | This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. |
| UniProt Protein Function: | PAX3: Probable transcription factor associated with development of alveolar rhabdomyosarcoma. Can bind to DNA as a heterodimer with PAX7. Interacts with DAXX. Belongs to the paired homeobox family. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 2q35 Cellular Component: nucleoplasm Molecular Function:protein binding; sequence-specific DNA binding Biological Process: apoptosis; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sensory perception of sound; transcription from RNA polymerase II promoter Disease: Craniofacial-deafness-hand Syndrome; Rhabdomyosarcoma 2; Waardenburg Syndrome, Type 1; Waardenburg Syndrome, Type 3 |
| NCBI Summary: | This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P23760 |
| NCBI GenInfo Identifier: | 1172022 |
| NCBI Gene ID: | 5077 |
| NCBI Accession: | P23760.2 |
| UniProt Secondary Accession: | P23760,Q16448, Q494Z3, Q494Z4, Q53T90, Q6GSJ9, Q86UQ2 Q86UQ3, G5E9C1, |
| UniProt Related Accession: | P23760 |
| Molecular Weight: | 55,975 Da |
| NCBI Full Name: | Paired box protein Pax-3 |
| NCBI Synonym Full Names: | paired box 3 |
| NCBI Official Symbol: | PAX3 |
| NCBI Official Synonym Symbols: | WS1; WS3; CDHS; HUP2 |
| NCBI Protein Information: | paired box protein Pax-3 |
| UniProt Protein Name: | Paired box protein Pax-3 |
| UniProt Synonym Protein Names: | HuP2 |
| Protein Family: | Paired box protein |
| UniProt Gene Name: | PAX3 |
| UniProt Entry Name: | PAX3_HUMAN |
 | Western blot analysis of extracts of 293T cells, using PAX3 antibody (CAB13930) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PAX3 antibody (CAB13930) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PAX3 antibody (CAB13930) at dilution of 1:100 (40x lens). |
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