Anti-PATZ1 Antibody (CAB10053)
- SKU:
- CAB10053
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-PATZ1 Antibody |
抗体コード: | CAB10053 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human PATZ1 (NP_114440.1). |
申し込み: | WB |
推奨希釈: | WB 1:1000 - 1:4000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HT-29, HeLa, MCF7, HL-60, HepG2, Mouse kidney, Mouse spleen, Mouse lung, Rat kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human PATZ1 (NP_114440.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PFPS VASS APPL TGKR GRGR PRKA NLLD SMFG SPGG LREA GILP CGLC GKVF TDAN RLRQ HEAQ HGVT SLQL GYID LPPP RLGE NGLP ISED PDGP RKRS R |
遺伝子ID: | 23598 |
Uniprot: | Q9HBE1 |
セルラーロケーション: | Nucleus |
計算された分子量: | 57kDa/69kDa/74kDa |
観察された分子量: | 74kDa |
同義語: | PATZ1, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23 |
バックグラウンド: | The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. |
UniProt Protein Function: | PATZ1: Transcriptional repressor. A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1. Belongs to the krueppel C2H2-type zinc-finger protein family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: nucleoplasm; nucleus Molecular Function:chromatin binding; DNA binding; metal ion binding Biological Process: male gonad development; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; spermatogenesis; T cell differentiation; transcription from RNA polymerase II promoter |
NCBI Summary: | The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HBE1 |
NCBI GenInfo Identifier: | 14670360 |
NCBI Gene ID: | 23598 |
NCBI Accession: | NP_055138.2 |
UniProt Secondary Accession: | Q9HBE1,Q9HBE2, Q9HBE3, Q9P1A9, Q9UDU0, Q9Y529, |
UniProt Related Accession: | Q9HBE1 |
Molecular Weight: | |
NCBI Full Name: | POZ-, AT hook-, and zinc finger-containing protein 1 long C isoform |
NCBI Synonym Full Names: | POZ/BTB and AT hook containing zinc finger 1 |
NCBI Official Symbol: | PATZ1 |
NCBI Official Synonym Symbols: | ZSG; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; dJ400N23 |
NCBI Protein Information: | POZ-, AT hook-, and zinc finger-containing protein 1 |
UniProt Protein Name: | POZ-, AT hook-, and zinc finger-containing protein 1 |
UniProt Synonym Protein Names: | BTB/POZ domain zinc finger transcription factor; Protein kinase A RI subunit alpha-associated protein; Zinc finger and BTB domain-containing protein 19; Zinc finger protein 278; Zinc finger sarcoma gene protein |
Protein Family: | POZ-, AT hook-, and zinc finger-containing protein |
UniProt Gene Name: | PATZ1 |
UniProt Entry Name: | PATZ1_HUMAN |
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