Anti-PARVB Antibody (CAB13161)
- SKU:
- CAB13161
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PARVB Antibody |
| 抗体コード: | CAB13161 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human PARVB (NP_037459.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, A375, HeLa, Mouse heart, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human PARVB (NP_037459.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSSA PRSP TPRP RRMK KDES FLGK LGGT LARK RRAR EVSD LQEE GKNA INSP MSPA LVDV HPED TQLE ENEE RTMI DPTS KEDP KFKE LVKV LLDW INDV |
| 遺伝子ID: | 29780 |
| Uniprot: | Q9HBI1 |
| セルラーロケーション: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, Z line, cytoskeleton, focal adhesion, lamellipodium, myofibril, sarcomere |
| 計算された分子量: | 37kDa/41kDa/45kDa |
| 観察された分子量: | 42kDa |
| 同義語: | PARVB, CGI-56 |
| バックグラウンド: | This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | PARVB: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Belongs to the parvin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 22q13.2-q13.33 Cellular Component: cytoskeleton; focal adhesion; lamellipodium; plasma membrane; cytosol; Z disc Molecular Function:protein binding; actin binding Biological Process: lamellipodium biogenesis; actin cytoskeleton reorganization; cell projection biogenesis; cell adhesion |
| NCBI Summary: | This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9HBI1 |
| NCBI GenInfo Identifier: | 20139178 |
| NCBI Gene ID: | 29780 |
| NCBI Accession: | Q9HBI1.1 |
| UniProt Secondary Accession: | Q9HBI1,Q5TGJ5, Q86X93, Q96PN1, Q9NSP7, Q9UGT3, Q9Y368 Q9Y3L6, Q9Y3L7, B0QYM8, B0QYN1, B2R9X6, |
| UniProt Related Accession: | Q9HBI1 |
| Molecular Weight: | 37,538 Da |
| NCBI Full Name: | Beta-parvin |
| NCBI Synonym Full Names: | parvin, beta |
| NCBI Official Symbol: | PARVB |
| NCBI Official Synonym Symbols: | CGI-56 |
| NCBI Protein Information: | beta-parvin; affixin |
| UniProt Protein Name: | Beta-parvin |
| UniProt Synonym Protein Names: | Affixin |
| Protein Family: | Beta-parvin |
| UniProt Gene Name: | PARVB |
| UniProt Entry Name: | PARVB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PARVB antibody (CAB13161) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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