Anti-PANX1 Antibody (CAB6683)
- SKU:
- CAB6683
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PANX1 Antibody |
| 抗体コード: | CAB6683 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PANX1 (NP_056183.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | DU145, HeLa, MCF7, Mouse skin, Mouse spleen, Mouse brain |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PANX1 (NP_056183.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ISLA FAQE ISIG TQIS CFSP SSFS WRQA AFVD SYCW AAVQ QKNS LQSE SGNL PLWL HKFF PYIL LLFA ILLY LPPL FWRF AAAP HICS DLKF IMEE LDKV Y |
| 遺伝子ID: | 24145 |
| Uniprot: | Q96RD7 |
| セルラーロケーション: | Cell junction, Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein, Multi-pass membrane protein, gap junction |
| 計算された分子量: | 47kDa/48kDa |
| 観察された分子量: | 54kDa |
| 同義語: | PANX1, MRS1, PX1, UNQ2529 |
| バックグラウンド: | The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. |
| UniProt Protein Function: | PANX1: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q21 Cellular Component: endoplasmic reticulum membrane; protein complex; membrane; endoplasmic reticulum; integral to membrane; plasma membrane; gap junction Molecular Function:actin filament binding; protease binding; leak channel activity; protein heterodimerization activity; gap junction hemi-channel activity; calcium channel activity; receptor binding Biological Process: positive regulation of interleukin-1 alpha secretion; synaptic transmission; calcium ion transport; innate immune response; positive regulation of interleukin-1 beta secretion; cation transport; response to ATP |
| NCBI Summary: | The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96RD7 |
| NCBI GenInfo Identifier: | 317373551 |
| NCBI Gene ID: | 24145 |
| NCBI Accession: | Q96RD7.4 |
| UniProt Secondary Accession: | Q96RD7,O75968, Q543A0, Q6UW26, Q96AM9, Q96L77, Q96RS5 |
| UniProt Related Accession: | Q96RD7 |
| Molecular Weight: | 426 |
| NCBI Full Name: | Pannexin-1 |
| NCBI Synonym Full Names: | pannexin 1 |
| NCBI Official Symbol: | PANX1 |
| NCBI Official Synonym Symbols: | PX1; MRS1; UNQ2529 |
| NCBI Protein Information: | pannexin-1; innexin |
| UniProt Protein Name: | Pannexin-1 |
| Protein Family: | Pannexin |
| UniProt Gene Name: | PANX1 |
| UniProt Entry Name: | PANX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PANX1 antibody (CAB6683) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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