Anti-PANX1 Antibody (CAB13587)
- SKU:
- CAB13587
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PANX1 Antibody |
| 抗体コード: | CAB13587 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-426 of human PANX1 (NP_056183.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Mouse ovary |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-426 of human PANX1 (NP_056183.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VPFR QKTD VLKV YEIL PTFD VLHF KSEG YNDL SLYN LFLE ENIS EVKS YKCL KVLE NIKS SGQG IDPM LLLT NLGM IKMD VVDG KTPM SAEM REEQ GNQT AELQ GMNI DSET KANN GEKN ARQR LLDS SC |
| 遺伝子ID: | 24145 |
| Uniprot: | Q96RD7 |
| セルラーロケーション: | Cell junction, Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein, Multi-pass membrane protein, gap junction |
| 計算された分子量: | 47kDa/48kDa |
| 観察された分子量: | 45kDa/60kDa |
| 同義語: | PANX1, MRS1, PX1, UNQ2529 |
| バックグラウンド: | The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. |
| UniProt Protein Function: | PANX1: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q21 Cellular Component: endoplasmic reticulum membrane; protein complex; membrane; endoplasmic reticulum; integral to membrane; plasma membrane; gap junction Molecular Function:actin filament binding; protease binding; leak channel activity; protein heterodimerization activity; gap junction hemi-channel activity; calcium channel activity; receptor binding Biological Process: positive regulation of interleukin-1 alpha secretion; synaptic transmission; calcium ion transport; innate immune response; positive regulation of interleukin-1 beta secretion; cation transport; response to ATP |
| NCBI Summary: | The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96RD7 |
| NCBI GenInfo Identifier: | 317373551 |
| NCBI Gene ID: | 24145 |
| NCBI Accession: | Q96RD7.4 |
| UniProt Secondary Accession: | Q96RD7,O75968, Q543A0, Q6UW26, Q96AM9, Q96L77, Q96RS5 |
| UniProt Related Accession: | Q96RD7 |
| Molecular Weight: | 426 |
| NCBI Full Name: | Pannexin-1 |
| NCBI Synonym Full Names: | pannexin 1 |
| NCBI Official Symbol: | PANX1 |
| NCBI Official Synonym Symbols: | PX1; MRS1; UNQ2529 |
| NCBI Protein Information: | pannexin-1; innexin |
| UniProt Protein Name: | Pannexin-1 |
| Protein Family: | Pannexin |
| UniProt Gene Name: | PANX1 |
| UniProt Entry Name: | PANX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PANX1 antibody (CAB13587) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of MCF7 cells using PANX1 antibody (CAB13587). Blue: DAPI for nuclear staining. |
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