Anti-PANK2 Antibody (CAB18502)
- SKU:
- CAB18502
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-PANK2 Antibody |
| 抗体コード: | CAB18502 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PANK2 (NP_705902.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse lung |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PANK2 (NP_705902.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 80025 |
| Uniprot: | Q9BZ23 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 63kDa |
 | Western blot - PANK2 Rabbit pAb (CAB18502) |
| 同義語: | C20orf48, HARP, HSS, NBIA1, PKAN, PANK2 |
| バックグラウンド: |
| UniProt Protein Function: | PANK2: a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK2 is predominantly localized in mitochondria in primates. Defects in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Three isoforms of the human PANK2, produced by alternative splicing, have been reported. |
| UniProt Protein Details: | Protein type:Mitochondrial; Kinase, other; EC 2.7.1.33; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytoplasm; mitochondrial intermembrane space Molecular Function:pantothenate kinase activity Biological Process: coenzyme biosynthetic process; regulation of fatty acid metabolic process Disease: Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, And Pallidal Degeneration; Neurodegeneration With Brain Iron Accumulation 1 |
| NCBI Summary: | This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BZ23 |
| NCBI GenInfo Identifier: | 118572682 |
| NCBI Gene ID: | 80025 |
| NCBI Accession: | Q9BZ23.3 |
| UniProt Secondary Accession: | Q9BZ23,Q5T7I2, Q5T7I4, Q7RTX5, Q8N7Q4, Q8TCR5, Q9BYW5 Q9HAF2, B1AK33, B2Z3X0, D3DVZ0, |
| UniProt Related Accession: | Q9BZ23 |
| Molecular Weight: | 50,582 Da |
| NCBI Full Name: | Pantothenate kinase 2, mitochondrial |
| NCBI Synonym Full Names: | pantothenate kinase 2 |
| NCBI Official Symbol: | PANK2 |
| NCBI Official Synonym Symbols: | HSS; HARP; PKAN; NBIA1; C20orf48 |
| NCBI Protein Information: | pantothenate kinase 2, mitochondrial |
| UniProt Protein Name: | Pantothenate kinase 2, mitochondrial |
| UniProt Synonym Protein Names: | Pantothenic acid kinase 2 |
| Protein Family: | Pantothenate kinase |
| UniProt Gene Name: | PANK2 |
| UniProt Entry Name: | PANK2_HUMAN |