| UniProt Protein Function: | Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. |
| NCBI Summary: | This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P19021 |
| NCBI GenInfo Identifier: | 21070984 |
| NCBI Gene ID: | 5066 |
| NCBI Accession: | NP_000910.2 |
| UniProt Related Accession: | P19021 |
| Molecular Weight: | 36kDa |
| NCBI Full Name: | peptidyl-glycine alpha-amidating monooxygenase isoform a |
| NCBI Synonym Full Names: | peptidylglycine alpha-amidating monooxygenase |
| NCBI Official Symbol: | PAM |
| NCBI Official Synonym Symbols: | PAL; PHM |
| NCBI Protein Information: | peptidyl-glycine alpha-amidating monooxygenase |
| UniProt Protein Name: | Peptidyl-glycine alpha-amidating monooxygenase |
| UniProt Synonym Protein Names: | Peptidylglycine alpha-hydroxylating monooxygenase (EC:1.14.17.3); PHMPeptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC:4.3.2.5)Alternative name(s):Peptidylamidoglycolate lyase; PAL |
| Protein Family: | Phenylalanine aminomutase |
| UniProt Gene Name: | PAM |
