Anti-PACS1 Antibody (CAB12659)
- SKU:
- CAB12659
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-PACS1 Antibody |
| 抗体コード: | CAB12659 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-560 of human PACS1 (NP_060496.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:3000 |
| 反応性: | Human |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-560 of human PACS1 (NP_060496.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SKGS LGKD TTSP MELA ALEK IKST WIKN QDDS LTET DTLE ITDQ DMFG DAST SLVV PEKV KTPM KSSK TDLQ GSAS PSKV EGVH TPRQ KRST PLKE RQLS KPLS ERTN SSDS ERSP DLGH STQI PRKV VYDQ LNQI LVSD A |
| 遺伝子ID: | 55690 |
| Uniprot: | Q6VY07 |
| セルラーロケーション: | Golgi apparatus, trans-Golgi network |
| 計算された分子量: | 104kDa/109kDa |
| 観察された分子量: | 105kDa |
| 同義語: | PACS1, MRD17, SHMS |
| バックグラウンド: | This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. |
| UniProt Protein Function: | PACS-1: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Belongs to the PACS family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11q13.1-q13.2 Cellular Component: cytosol Molecular Function:protein binding Biological Process: regulation of defense response to virus by virus Disease: Mental Retardation, Autosomal Dominant 17 |
| NCBI Summary: | This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6VY07 |
| NCBI GenInfo Identifier: | 52000804 |
| NCBI Gene ID: | 55690 |
| NCBI Accession: | Q6VY07.2 |
| UniProt Secondary Accession: | Q6VY07,Q6PJY6, Q6PKB6, Q7Z590, Q7Z5W4, Q8N8K6, Q96MW0 Q9NW92, Q9ULP5, |
| UniProt Related Accession: | Q6VY07 |
| Molecular Weight: | 105kDa |
| NCBI Full Name: | Phosphofurin acidic cluster sorting protein 1 |
| NCBI Synonym Full Names: | phosphofurin acidic cluster sorting protein 1 |
| NCBI Official Symbol: | PACS1 |
| NCBI Official Synonym Symbols: | SHMS; MRD17 |
| NCBI Protein Information: | phosphofurin acidic cluster sorting protein 1 |
| UniProt Protein Name: | Phosphofurin acidic cluster sorting protein 1 |
| Protein Family: | Phosphofurin acidic cluster sorting protein |
| UniProt Gene Name: | PACS1 |
 | Western blot analysis of extracts of 293T cells, using PACS1 antibody (CAB12659) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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