Anti-PACRG Antibody (CAB15956)
- SKU:
- CAB15956
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PACRG Antibody |
| 抗体コード: | CAB15956 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human PACRG (NP_001073847.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, A-549, BxPC-3, Raji, Mouse testis, Mouse lung, Rat testis |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human PACRG (NP_001073847.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IIPI KNAL NLRN RQVI CVTL KVLQ HLVV SAEM VGKA LVPY YRQI LPVL NIFK NMNV NSGD GIDY SQQK RENI GDLI QETL EAFE RYGG ENAF INIK YVVP T |
| 遺伝子ID: | 135138 |
| Uniprot: | Q96M98 |
| セルラーロケーション: | |
| 計算された分子量: | 29kDa/33kDa |
| 観察された分子量: | 35kDa |
| 同義語: | PACRG, GLUP, HAK005771, PARK2CRG |
| バックグラウンド: | This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PACRG: Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 6q26 Cellular Component: cytosol; neuron projection; nucleus; vesicle Molecular Function:actin binding; alpha-tubulin binding; beta-tubulin binding; chaperone binding; G-protein-coupled receptor binding; heat shock protein binding; Hsp70 protein binding; Hsp90 protein binding; ubiquitin protein ligase binding Disease: Leprosy, Susceptibility To, 2 |
| NCBI Summary: | This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96M98 |
| NCBI GenInfo Identifier: | 77416872 |
| NCBI Gene ID: | 135138 |
| NCBI Accession: | Q96M98.2 |
| UniProt Secondary Accession: | Q96M98,Q6IMB8, Q8IZM1, Q8NHP5, Q9H1V9, E1P5B5, |
| UniProt Related Accession: | Q96M98 |
| Molecular Weight: | 29,312 Da |
| NCBI Full Name: | Parkin coregulated gene protein |
| NCBI Synonym Full Names: | PARK2 coregulated |
| NCBI Official Symbol: | PACRG |
| NCBI Official Synonym Symbols: | GLUP; PARK2CRG; HAK005771 |
| NCBI Protein Information: | parkin coregulated gene protein |
| UniProt Protein Name: | Parkin coregulated gene protein |
| UniProt Synonym Protein Names: | Molecular chaperone/chaperonin-binding protein; PARK2 coregulated gene protein |
| Protein Family: | PACRG-like protein |
| UniProt Gene Name: | PACRG |
| UniProt Entry Name: | PACRG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PACRG antibody (CAB15956) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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