Anti-P2RY6 Antibody (CAB2485)
- SKU:
- CAB2485
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-P2RY6 Antibody |
| 抗体コード: | CAB2485 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human P2RY6 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | MCF7, Mouse lung, Mouse brain |
| 免疫原: | Recombinant protein of human P2RY6 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 5031 |
| Uniprot: | Q15077 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 36kDa |
| 観察された分子量: | 42kDa |
| 同義語: | P2RY6, P2Y6 |
| バックグラウンド: | The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. |
| UniProt Protein Function: | P2Y6: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; UDP-activated nucleotide receptor activity; purinergic nucleotide receptor activity, G-protein coupled Biological Process: transepithelial chloride transport; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of smooth muscle cell migration |
| NCBI Summary: | The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013] |
| UniProt Code: | Q15077 |
| NCBI GenInfo Identifier: | 2495018 |
| NCBI Gene ID: | 5031 |
| NCBI Accession: | Q15077.1 |
| UniProt Related Accession: | Q15077 |
| Molecular Weight: | 36kDa |
| NCBI Full Name: | P2Y purinoceptor 6 |
| NCBI Synonym Full Names: | pyrimidinergic receptor P2Y6 |
| NCBI Official Symbol: | P2RY6 |
| NCBI Official Synonym Symbols: | P2Y6 |
| NCBI Protein Information: | P2Y purinoceptor 6 |
| UniProt Protein Name: | P2Y purinoceptor 6 |
| UniProt Gene Name: | P2RY6 |
| UniProt Entry Name: | P2RY6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using P2RY6 antibody (CAB2485) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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