Anti-P2RY2 Antibody (CAB5779)
- SKU:
- CAB5779
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-P2RY2 Antibody |
| 抗体コード: | CAB5779 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 278-377 of human P2RY2 (NP_788086.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse liver, Mouse heart, Mouse skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 278-377 of human P2RY2 (NP_788086.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CHTL NAIN MAYK VTRP LASA NSCL DPVL YFLA GQRL VRFA RDAK PPTG PSPA TPAR RRLG LRRS DRTD MQRI EDVL GSSE DSRR TEST PAGS ENTK DIRL |
| 遺伝子ID: | 5029 |
| Uniprot: | P41231 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 42kDa |
| 観察された分子量: | 50kDa |
| 同義語: | P2RY2, HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R |
| バックグラウンド: | The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. |
| UniProt Protein Function: | P2Y2: a G-protein coupled receptor of the rhodopsin family. This family includes hormone, neurotransmitter and light receptors. Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. May participate in control of the cell cycle and proliferation. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, multi-pass; Receptor, misc.; GPCR, family 1; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13.5-q14.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:purinergic nucleotide receptor activity, G-protein coupled; receptor activity Biological Process: regulation of vasodilation; cellular ion homeostasis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) |
| NCBI Summary: | The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P41231 |
| NCBI GenInfo Identifier: | 311033490 |
| NCBI Gene ID: | 5029 |
| NCBI Accession: | P41231.4 |
| UniProt Secondary Accession: | P41231,Q96EM8, B2R9W3, |
| UniProt Related Accession: | P41231 |
| Molecular Weight: | 377 |
| NCBI Full Name: | P2Y purinoceptor 2 |
| NCBI Synonym Full Names: | purinergic receptor P2Y, G-protein coupled, 2 |
| NCBI Official Symbol: | P2RY2 |
| NCBI Official Synonym Symbols: | P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R |
| NCBI Protein Information: | P2Y purinoceptor 2; ATP receptor; P2U receptor 1; purinoceptor P2Y2; P2U purinoceptor 1; P2U nucleotide receptor; purinergic receptor P2Y2 |
| UniProt Protein Name: | P2Y purinoceptor 2 |
| UniProt Synonym Protein Names: | ATP receptor; P2U purinoceptor 1; P2U1; P2U receptor 1; Purinergic receptor |
| Protein Family: | P2Y purinoceptor |
| UniProt Gene Name: | P2RY2 |
| UniProt Entry Name: | P2RY2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using P2RY2 antibody (CAB5779) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of U2OS cells using P2RY2 antibody (CAB5779). Blue: DAPI for nuclear staining. |
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