Anti-P2RX2 Antibody (CAB7078)
- SKU:
- CAB7078
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-P2RX2 Antibody |
| 抗体コード: | CAB7078 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human P2RX2 (NP_733782.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, BT-474, HepG2, HL-60, Mouse liver, Mouse testis, Mouse heart, Rat liver, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human P2RX2 (NP_733782.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VFIV QKSY QESE TGPE SSII TKVK GITT SEHK VWDV EEYV KPPE GGSV FSII TRVE ATHS QTQG TCPE SIRV HNAT CLSD ADCV AGEL DMLG NGLR TGRC VPYY QGPS KTCE VFGW CPVE DGAS VSQF LGTM APNF TILI KNSI HYPK FHFS KGNI ADRT DGYL KRCT FHEA SDLY CPIF KLGF IVEK AGES FTEL AHKG GVIG VIIN WDCD LDLP ASEC NPKY SFRR LDPK HVPA SSGY NFRF AKYY KING TTTR TLIK A |
| 遺伝子ID: | 22953 |
| Uniprot: | Q9UBL9 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 41kDa/43kDa/44kDa/49kDa/51kDa/54kDa |
| 観察された分子量: | 50-52kDa |
| 同義語: | P2RX2, DFNA41, P2X2 |
| バックグラウンド: | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | P2X2: Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral; Channel, cation Chromosomal Location of Human Ortholog: 12q24.33 Cellular Component: presynaptic membrane; cell surface; cell soma; integral to plasma membrane; apical plasma membrane; postsynaptic density; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex Molecular Function:identical protein binding; zinc ion binding; mercury ion binding; drug binding; cadmium ion binding; ligand-gated ion channel activity; phosphoinositide binding; purinergic nucleotide receptor activity; nickel ion binding; copper ion binding; cobalt ion binding; ATP binding; ATP-gated cation channel activity Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; protein heterooligomerization; generation of action potential; skeletal muscle fiber development; positive regulation of calcium-mediated signaling; detection of hypoxic conditions in blood by carotid body chemoreceptors; response to carbohydrate stimulus; response to ATP; behavioral response to pain; sensory perception of sound; response to hypoxia; neuromuscular synaptic transmission; protein homooligomerization; neuromuscular junction development Disease: Deafness, Autosomal Dominant 41 |
| NCBI Summary: | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9UBL9 |
| NCBI GenInfo Identifier: | 12643353 |
| NCBI Gene ID: | 22953 |
| NCBI Accession: | Q9UBL9.1 |
| UniProt Secondary Accession: | Q9UBL9,Q6V9R6, Q9NR37, Q9NR38, Q9UHD5, Q9UHD6, Q9UHD7 A6NGB4, A6NH93, A6NHC2, A6NHU3, A6NIG9, |
| UniProt Related Accession: | Q9UBL9 |
| Molecular Weight: | 471 |
| NCBI Full Name: | P2X purinoceptor 2 |
| NCBI Synonym Full Names: | purinergic receptor P2X, ligand-gated ion channel, 2 |
| NCBI Official Symbol: | P2RX2 |
| NCBI Official Synonym Symbols: | P2X2; DFNA41 |
| NCBI Protein Information: | P2X purinoceptor 2; ATP receptor; P2X Receptor, subunit 2 |
| UniProt Protein Name: | P2X purinoceptor 2 |
| UniProt Synonym Protein Names: | ATP receptor; Purinergic receptor |
| Protein Family: | P2X purinoceptor |
| UniProt Gene Name: | P2RX2 |
| UniProt Entry Name: | P2RX2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using P2RX2 antibody (CAB7078) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |