| UniProt Protein Function: | OVOL2: DNA-binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. Probably acts as a transcription regulator. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 20p11.23 Cellular Component: nucleus Disease: Corneal Dystrophy, Posterior Polymorphous, 1 |
| NCBI Summary: | This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016] |
| UniProt Code: | Q9BRP0 |
| NCBI GenInfo Identifier: | 743405586 |
| NCBI Gene ID: | 58495 |
| NCBI Accession: | NP_001290390.1 |
| UniProt Secondary Accession: | Q9BRP0,Q5T8B4, Q9BX22, Q9HA54, Q9Y4M0, |
| UniProt Related Accession: | Q9BRP0 |
| Molecular Weight: | 16,565 Da |
| NCBI Full Name: | transcription factor Ovo-like 2 isoform 2 |
| NCBI Synonym Full Names: | ovo like zinc finger 2 |
| NCBI Official Symbol: | OVOL2 |
| NCBI Official Synonym Symbols: | PPCD1; ZNF339; EUROIMAGE566589 |
| NCBI Protein Information: | transcription factor Ovo-like 2 |
| UniProt Protein Name: | Transcription factor Ovo-like 2 |
| UniProt Synonym Protein Names: | Zinc finger protein 339 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | OVOL2 |
| UniProt Entry Name: | OVOL2_HUMAN |
