Anti-OSTM1 Antibody (CAB11685)
- SKU:
- CAB11685
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-OSTM1 Antibody |
| 抗体コード: | CAB11685 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-284 of human OSTM1 (NP_054747.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, 293T, A-549, Raji, B cells, Mouse brain, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-284 of human OSTM1 (NP_054747.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ALPF GSSP HRVF HDLL SEQQ LLEV EDLS LSLL QGGG LGPL SLPP DLPD LDPE CREL LLDF ANSS AELT GCLV RSAR PVRL CQTC YPLF QQVV SKMD NISR AAGN TSES QSCA RSLL MADR MQIV VILS EFFN TTWQ EANC ANCL TNNS EELS NSTV YFLN LFNH TLTC FEHN LQGN AHSL LQTK NYSE VCKN CREA YKTL SSLY SEMQ KMNE LENK AEPG THLC IDVE DAMN ITRK LWSR TFNC SVPC SDTV P |
| 遺伝子ID: | 28962 |
| Uniprot: | Q86WC4 |
| セルラーロケーション: | Lysosome membrane, Single-pass type I membrane protein |
| 計算された分子量: | 37kDa |
| 観察された分子量: | 30-37kDa |
| 同義語: | OSTM1, GIPN, GL, HSPC019, OPTB5 |
| バックグラウンド: | This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. |
| UniProt Protein Function: | OSTM1: Required for osteoclast and melanocyte maturation and function. Defects in OSTM1 are the cause of osteopetrosis autosomal recessive type 5 (OPTB5); also called infantile malignant osteopetrosis 3. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTB5 patients manifest primary central nervous system involvement in addition to the classical stigmata of severe bone sclerosis, growth failure, anemia, thrombocytopenia and visual impairment with optic atrophy. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 6q21 Cellular Component: lysosomal membrane Disease: Osteopetrosis, Autosomal Recessive 5 |
| NCBI Summary: | This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86WC4 |
| NCBI GenInfo Identifier: | 51316434 |
| NCBI Gene ID: | 28962 |
| NCBI Accession: | Q86WC4.1 |
| UniProt Secondary Accession: | Q86WC4,Q5R391, Q6PCA7, Q7RTW6, Q8NC29, Q8TC82, Q9Y2S9 E1P5E3, |
| UniProt Related Accession: | Q86WC4 |
| Molecular Weight: | 37kDa |
| NCBI Full Name: | Osteopetrosis-associated transmembrane protein 1 |
| NCBI Synonym Full Names: | osteopetrosis associated transmembrane protein 1 |
| NCBI Official Symbol: | OSTM1 |
| NCBI Official Synonym Symbols: | GL; GIPN; OPTB5; HSPC019 |
| NCBI Protein Information: | osteopetrosis-associated transmembrane protein 1 |
| UniProt Protein Name: | Osteopetrosis-associated transmembrane protein 1 |
| UniProt Synonym Protein Names: | Chloride channel 7 beta subunit |
| Protein Family: | Osteopetrosis-associated transmembrane protein |
| UniProt Gene Name: | OSTM1 |
 | Western blot analysis of extracts of various cell lines, using OSTM1 antibody (CAB11685) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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