Anti-OS9 Antibody (CAB12261)
- SKU:
- CAB12261
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-OS9 Antibody |
| 抗体コード: | CAB12261 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 353-612 of human OS9 (NP_001017956.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-87MG, LO2, BxPC-3, B cells, HeLa, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 353-612 of human OS9 (NP_001017956.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NVQV KVIR SPAD LIRF IEEL KGGT KKGK PNIG QEQP VDDA AEVP QREP EKER GDPE RQRE MEEE EDED EDED EDED ERQL LGEF EKEL EGIL LPSD RDRL RSEV KAGM EREL ENII QETE KELD PDGL KKES ERDR AMLA LTST LNKL IKRL EEKQ SPEL VKKH KKKR VVPK KPPP SPQP TGKI EIKI VRPW AEGT EEGA RWLT DEDT RNLK EIFF NILV PGAE EAQK ERQR QKEL ESNY RRVW GSPG GEGT GDLD EFDF |
| 遺伝子ID: | 10956 |
| Uniprot: | Q13438 |
| セルラーロケーション: | Endoplasmic reticulum lumen |
| 計算された分子量: | 60kDa/63kDa/65kDa/67kDa/69kDa/73kDa/75kDa |
| 観察された分子量: | 70kDa |
| 同義語: | OS9, ERLEC2, OS-9 |
| バックグラウンド: | This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
| UniProt Protein Function: | OS9: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Belongs to the OS-9 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum Chromosomal Location of Human Ortholog: 12q13 Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane Molecular Function:glycoprotein binding; protein binding Biological Process: ER-associated protein catabolic process; protein retention in ER; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process |
| NCBI Summary: | This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13438 |
| NCBI GenInfo Identifier: | 3024310 |
| NCBI Gene ID: | 10956 |
| NCBI Accession: | Q13438.1 |
| UniProt Secondary Accession: | Q13438,A6NDD1, A6NFR7, A6NLB2, A8K5Q9, B4DE28, B4DPX1 B4E1I6, E7ENT8, E7EW91, F8VUH2, G3XA88, |
| UniProt Related Accession: | Q13438 |
| Molecular Weight: | 60,847 Da |
| NCBI Full Name: | Protein OS-9 |
| NCBI Synonym Full Names: | OS9, endoplasmic reticulum lectin |
| NCBI Official Symbol: | OS9 |
| NCBI Official Synonym Symbols: | OS-9; ERLEC2 |
| NCBI Protein Information: | protein OS-9 |
| UniProt Protein Name: | Protein OS-9 |
| UniProt Synonym Protein Names: | Amplified in osteosarcoma 9 |
| Protein Family: | Protein |
| UniProt Gene Name: | OS9 |
| UniProt Entry Name: | OS9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OS9 antibody (CAB12261) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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