Anti-ORMDL3 Antibody (CAB14951)
- SKU:
- CAB14951
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ORMDL3 Antibody |
| 抗体コード: | CAB14951 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ORMDL3 (NP_644809.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, Mouse eye, Mouse thymus, Mouse liver |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ORMDL3 (NP_644809.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNVG TAHS EVNP NTRV MNSR GIWL SYVL AIGL LHIV LLSI PFVS VPVV WTLT NLIH NMGM YIFL HTVK GTPF ETPD QGKA RLLT HWEQ MDYG VQFT ASRK |
| 遺伝子ID: | 94103 |
| Uniprot: | Q8N138 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
| 計算された分子量: | 15kDa/17kDa |
| 観察された分子量: | 17kDa |
| 同義語: | ORMDL3 |
| バックグラウンド: |
| UniProt Protein Function: | ORMDL3: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. Genetic variations in ORMDL3 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Belongs to the ORM family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q12 Cellular Component: endoplasmic reticulum Molecular Function:protein binding Biological Process: ceramide metabolic process |
| UniProt Code: | Q8N138 |
| NCBI GenInfo Identifier: | 74728486 |
| NCBI Gene ID: | 94103 |
| NCBI Accession: | Q8N138.1 |
| UniProt Secondary Accession: | Q8N138,Q6UY83, B3KS83, |
| UniProt Related Accession: | Q8N138 |
| Molecular Weight: | 15,689 Da |
| NCBI Full Name: | ORM1-like protein 3 |
| NCBI Synonym Full Names: | ORMDL sphingolipid biosynthesis regulator 3 |
| NCBI Official Symbol: | ORMDL3 |
| NCBI Protein Information: | ORM1-like protein 3 |
| UniProt Protein Name: | ORM1-like protein 3 |
| Protein Family: | ORM1-like protein |
| UniProt Gene Name: | ORMDL3 |
| UniProt Entry Name: | ORML3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ORMDL3 antibody (CAB14951) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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