Anti-ORC5 Antibody (CAB18343)
- SKU:
- CAB18343
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-ORC5 Antibody |
| 抗体コード: | CAB18343 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human ORC5. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human ORC5. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 5001 |
| Uniprot: | O43913 |
| セルラーロケーション: | |
| 計算された分子量: | 50kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | ORC5, ORC5L, ORC5P, ORC5T, PPP1R117 |
| バックグラウンド: | The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| UniProt Protein Function: | ORC5L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC5 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: nucleoplasm; cytoplasm; nuclear origin of replication recognition complex; nucleus; origin recognition complex Molecular Function:protein binding; nucleotide binding; DNA replication origin binding; ATP binding Biological Process: DNA replication initiation; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle |
| NCBI Summary: | The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010] |
| UniProt Code: | O43913 |
| NCBI GenInfo Identifier: | 6174924 |
| NCBI Gene ID: | 5001 |
| NCBI Accession: | O43913.1 |
| UniProt Secondary Accession: | O43913,O60590, O95268, A4D0P8, |
| UniProt Related Accession: | O43913 |
| Molecular Weight: | 435 |
| NCBI Full Name: | Origin recognition complex subunit 5 |
| NCBI Synonym Full Names: | origin recognition complex, subunit 5 |
| NCBI Official Symbol: | ORC5 |
| NCBI Official Synonym Symbols: | ORC5L; ORC5P; ORC5T; PPP1R117 |
| NCBI Protein Information: | origin recognition complex subunit 5; protein phosphatase 1, regulatory subunit 117 |
| UniProt Protein Name: | Origin recognition complex subunit 5 |
| Protein Family: | Origin recognition complex |
| UniProt Gene Name: | ORC5 |
| UniProt Entry Name: | ORC5_HUMAN |