Anti-ORC2 Antibody (CAB15697)
- SKU:
- CAB15697
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-ORC2 Antibody |
抗体コード: | CAB15697 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 458-577 of human ORC2 (NP_006181.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HeLa, 293T |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 458-577 of human ORC2 (NP_006181.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TSYE NSLL VKQS GSLP LSSL THVL RSLT PNAR GIFR LLIK YQLD NQDN PSYI GLSF QDFY QQCR EAFL VNSD LTLR AQLT EFRD HKLI RTKK GTDG VEYL LIPV DNGT LTDF LEKE EEEA |
遺伝子ID: | 4999 |
Uniprot: | Q13416 |
セルラーロケーション: | Nucleus |
計算された分子量: | 65kDa |
観察された分子量: | 80kDa |
同義語: | ORC2, ORC2L |
バックグラウンド: | The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. |
UniProt Protein Function: | ORC2: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Interacts with MCM10. Belongs to the ORC2 family. |
UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 2q33 Cellular Component: centrosome; heterochromatin; membrane; nuclear chromosome, telomeric region; nuclear origin of replication recognition complex; nucleoplasm; nucleus; origin recognition complex Molecular Function:protein binding Biological Process: DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010] |
UniProt Code: | Q13416 |
NCBI GenInfo Identifier: | 8488999 |
NCBI Gene ID: | 4999 |
NCBI Accession: | Q13416.2 |
UniProt Secondary Accession: | Q13416,Q13204, Q53TX5, |
UniProt Related Accession: | Q13416 |
Molecular Weight: | 65,972 Da |
NCBI Full Name: | Origin recognition complex subunit 2 |
NCBI Synonym Full Names: | origin recognition complex subunit 2 |
NCBI Official Symbol: | ORC2 |
NCBI Official Synonym Symbols: | ORC2L |
NCBI Protein Information: | origin recognition complex subunit 2 |
UniProt Protein Name: | Origin recognition complex subunit 2 |
Protein Family: | Origin recognition complex |
UniProt Gene Name: | ORC2 |
UniProt Entry Name: | ORC2_HUMAN |
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