Anti-ORAI1 Antibody (CAB7412)
- SKU:
- CAB7412
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-ORAI1 Antibody |
抗体コード: | CAB7412 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 202-301 of human ORAI1 (NP_116179.2). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SKOV3, DU145, HeLa, MCF7, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 202-301 of human ORAI1 (NP_116179.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LKKQ PGQP RPTS KPPA SGAA ANVS TSGI TPGQ AAAI ASTT IMVP FGLI FIVF AVHF YRSL VSHK TDRQ FQEL NELA EFAR LQDQ LDHR GDHP LTPG SHYA |
遺伝子ID: | 84876 |
Uniprot: | Q96D31 |
セルラーロケーション: | Cell membrane, Cytoplasmic vesicle, Multi-pass membrane protein, autophagosome |
計算された分子量: | 25kDa/32kDa |
観察された分子量: | 37kDa |
同義語: | CRACM1, IMD9, ORAT1, TAM2, TMEM142A, ORAI1 |
バックグラウンド: | The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). |
UniProt Protein Function: | ORAI1: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Belongs to the Orai family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: protein complex; membrane; integral to plasma membrane Molecular Function:calmodulin binding; identical protein binding; protein binding; store-operated calcium channel activity Biological Process: immune system process; regulation of calcium ion transport; positive regulation of calcium ion transport; blood coagulation Disease: Myopathy, Tubular Aggregate, 2; Immunodeficiency 9 |
NCBI Summary: | The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] |
UniProt Code: | Q96D31 |
NCBI GenInfo Identifier: | 97180269 |
NCBI Gene ID: | 84876 |
NCBI Accession: | Q96D31.2 |
UniProt Secondary Accession: | Q96D31,Q5M848, Q8BWG9, Q6TLE6, Q5ZL05, |
UniProt Related Accession: | Q96D31 |
Molecular Weight: | 25,337 Da |
NCBI Full Name: | Calcium release-activated calcium channel protein 1 |
NCBI Synonym Full Names: | ORAI calcium release-activated calcium modulator 1 |
NCBI Official Symbol: | ORAI1 |
NCBI Official Synonym Symbols: | IMD9; TAM2; ORAT1; CRACM1; TMEM142A |
NCBI Protein Information: | calcium release-activated calcium channel protein 1; protein orai-1; transmembrane protein 142A; calcium release-activated calcium modulator 1 |
UniProt Protein Name: | Calcium release-activated calcium channel protein 1 |
UniProt Synonym Protein Names: | Protein orai-1; Transmembrane protein 142A |
UniProt Gene Name: | ORAI1 |
UniProt Entry Name: | CRCM1_HUMAN |
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