Anti-OR10H3 Antibody (CAB17133)
- SKU:
- CAB17133
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Description
| 抗体名: | Anti-OR10H3 Antibody |
| 抗体コード: | CAB17133 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human OR10H3 (NP_039227.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2 |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human OR10H3 (NP_039227.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MLGL NHTS MSEF ILVG FSAF PHLQ LMLF LLFL LMYL FTLL GNLL IMAT VWSE RSLH TPMY LFLC VLSV SEIL YTVA IIPR MLAD LLST QRSI AFLA CASQ |
| 遺伝子ID: | 26532 |
| Uniprot: | O60404 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 36kDa |
 | Western blot - OR10H3 Rabbit pAb (CAB17133) |
| 同義語: | OR10H3 |
| バックグラウンド: | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. |
| UniProt Protein Function: | IKKA: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B, leading to their dissociation from NF-kappa-B and ultimately to their degradation. Phosphorylated and activated downstream of growth factor receptors, IL1R, and TNFR by NAK, IRAK and NIK, respectively. Preferentially found as a heterodimer with IKK-beta but also as an homodimer. Directly interacts with IKK-gamma/NEMO and TRPC4AP. Heterodimers form the active complex. The tripartite complex can also bind to MAP3K14/NIK, MEKK1, IKAP and IKB-alpha-p65-p50 complex. Inhibitors are under development to treat arthritis, inflammation, and apoptotic aspects of cancer. Aspirin (sodium salicylate) selectively binds IKK and reduces inflammation. Misexpression and inhibitors show involvement in insulin sensitization in obese rodents. Mutations in IKK-gamma are found in several immune deficiencies: hyper IgM syndrome, incontinentia pigmenti [embryonic lethal in males, defects in skin, hair, teeth in females] and hypohidrotic ectodermal dysplasia; recurrent infections and defects in teeth, hair, and sweat glands]. Inhibitors: CHS 828, NBD peptide, BMS-345541. |
| UniProt Protein Details: | Protein type:Protein kinase, Other; EC 2.7.11.10; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family Chromosomal Location of Human Ortholog: 10q24-q25 Cellular Component: nucleoplasm; internal side of plasma membrane; intracellular membrane-bound organelle; cytoplasm; IkappaB kinase complex; cytosol Molecular Function:protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; ATP binding; protein kinase activity Biological Process: skeletal muscle contraction; lactation; I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; response to toxin; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; osteoclast differentiation; T cell receptor signaling pathway; protein amino acid phosphorylation; Rho protein signal transduction; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; positive regulation of interferon type I production; morphogenesis of an epithelial sheet; inflammatory response; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; response to drug; anatomical structure morphogenesis; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to virus; MyD88-independent toll-like receptor signaling pathway; mammary gland epithelial cell proliferation; response to amino acid stimulus; odontogenesis of dentine-containing teeth; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to hydroperoxide; toll-like receptor signaling pathway; innate immune response; striated muscle cell differentiation; immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation Disease: Cocoon Syndrome |
| NCBI Summary: | This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60404 |
| NCBI GenInfo Identifier: | 62241001 |
| NCBI Gene ID: | 1147 |
| NCBI Accession: | NP_001269.3 |
| UniProt Secondary Accession: | O60404,Q8NGA5, |
| UniProt Related Accession: | O15111 |
| Molecular Weight: | 84,640 Da |
| NCBI Full Name: | inhibitor of nuclear factor kappa-B kinase subunit alpha |
| NCBI Synonym Full Names: | conserved helix-loop-helix ubiquitous kinase |
| NCBI Official Symbol: | CHUK |
| NCBI Official Synonym Symbols: | IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha |
| NCBI Protein Information: | inhibitor of nuclear factor kappa-B kinase subunit alpha; TCF-16; IKK-a kinase; I-kappa-B kinase 1; I-kappa-B kinase-alpha; transcription factor 16; IkB kinase alpha subunit; Nuclear factor NFkappaB inhibitor kinase alpha |
| UniProt Protein Name: | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
| UniProt Synonym Protein Names: | Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16 |
| Protein Family: | Inhibitor of nuclear factor kappa-B kinase |
| UniProt Gene Name: | CHUK |
| UniProt Entry Name: | IKKA_HUMAN |