Anti-OPHN1 Antibody (CAB6940)
- SKU:
- CAB6940
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-OPHN1 Antibody |
| 抗体コード: | CAB6940 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human OPHN1 (NP_002538.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HepG2, Mouse spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human OPHN1 (NP_002538.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGHP PLEF SDCY LDSP DFRE RLKC YEQE LERT NKFI KDVI KDGN ALIS AMRN YSSA VQKF SQTL QSFQ FDFI GDTL TDDE INIA ESFK EFAE LLNE VENE RMMM VHNA SDLL IKPL ENFR KEQI GFTK ERKK KFEK DGER FYSL LDRH LHLS SKKK ESQL QEAD LQVD KERH NFFE SSLD YVYQ IQEV QESK KFNI VEPV LAFL HSLF ISNS LTVE LTQD FLPY KQQL QLSL QNTR NHFS STRE EMEE LKKR MKEA PQTC KLPG QPTI EG |
| 遺伝子ID: | 4983 |
| Uniprot: | O60890 |
| セルラーロケーション: | Cell junction, Cell projection, Cytoplasm, axon, dendrite, dendritic spine, synapse |
| 計算された分子量: | 36kDa/91kDa |
| 観察された分子量: | 92kDa |
| 同義語: | OPHN1, ARHGAP41, MRX60, OPN1 |
| バックグラウンド: | This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism. |
| UniProt Protein Function: | OPHN1: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Defects in OPHN1 are the cause of mental retardation X- linked OPHN1-related (MRXSO); formerly designated MRX60. MRXSO is a syndromic mental retardation. Patients present mental retardation associated with cerebellar hypoplasia and distinctive facial dysmorphism. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: Xq12 Cellular Component: dendritic spine; terminal button; cell junction; cytosol; actin cytoskeleton Molecular Function:ionotropic glutamate receptor binding; phospholipid binding; actin binding Biological Process: nervous system development; axon guidance; regulation of small GTPase mediated signal transduction; regulation of synaptic transmission, glutamatergic; small GTPase mediated signal transduction; synaptic vesicle endocytosis; regulation of endocytosis; actin cytoskeleton organization and biogenesis; signal transduction; substrate-bound cell migration, cell extension Disease: Mental Retardation, X-linked, With Cerebellar Hypoplasia And Distinctive Facial Appearance |
| NCBI Summary: | This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60890 |
| NCBI GenInfo Identifier: | 21759325 |
| NCBI Gene ID: | 4983 |
| NCBI Accession: | O60890.1 |
| UniProt Secondary Accession: | O60890,Q5JQ81, Q6PCC1, Q8WX47, B9EIP8, |
| UniProt Related Accession: | O60890 |
| Molecular Weight: | 802 |
| NCBI Full Name: | Oligophrenin-1 |
| NCBI Synonym Full Names: | oligophrenin 1 |
| NCBI Official Symbol: | OPHN1 |
| NCBI Official Synonym Symbols: | OPN1; MRX60; ARHGAP41 |
| NCBI Protein Information: | oligophrenin-1; mental retardation, X-linked 60; oligophrenin-1, Rho-GTPase activating protein |
| UniProt Protein Name: | Oligophrenin-1 |
| Protein Family: | Oligophrenin |
| UniProt Gene Name: | OPHN1 |
| UniProt Entry Name: | OPHN1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OPHN1 Antibody (CAB6940) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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