Anti-ONECUT1 Antibody (CAB9668)
- SKU:
- CAB9668
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-ONECUT1 Antibody |
抗体コード: | CAB9668 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 167-292 of human ONECUT1 (NP_004489.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | Mouse spleen |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 167-292 of human ONECUT1 (NP_004489.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PYHK DVAG MGQS LSPL SSSG LGSI HNSQ QGLP HYAH PGAA MPTD KMLT PNGF EAHH PAML GRHG EQHL TPTS AGMV PING LPPH HPHA HLNA QGHG QLLG TARE PNPS VTGA QVSN GSNS GQME EI |
遺伝子ID: | 3175 |
Uniprot: | Q9UBC0 |
セルラーロケーション: | Nucleus |
計算された分子量: | 51kDa |
観察された分子量: | 55kDa |
同義語: | ONECUT1, HNF-6, HNF6, HNF6A |
バックグラウンド: | This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | ONECUT1: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Belongs to the CUT homeobox family. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 15q21.3 Cellular Component: nucleus Molecular Function:DNA binding Biological Process: spleen development; cell fate commitment; transcription, DNA-dependent; regulation of cell-matrix adhesion; system development; glucose metabolic process; liver development; endocrine pancreas development; regulation of transcription, DNA-dependent; B cell differentiation; epithelial cell development; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; endoderm development |
NCBI Summary: | This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
UniProt Code: | Q9UBC0 |
NCBI GenInfo Identifier: | 13627184 |
NCBI Gene ID: | 3175 |
NCBI Accession: | Q9UBC0.1 |
UniProt Related Accession: | Q9UBC0 |
Molecular Weight: | |
NCBI Full Name: | Hepatocyte nuclear factor 6 |
NCBI Synonym Full Names: | one cut homeobox 1 |
NCBI Official Symbol: | ONECUT1 |
NCBI Official Synonym Symbols: | HNF6; HNF-6; HNF6A |
NCBI Protein Information: | hepatocyte nuclear factor 6 |
UniProt Protein Name: | Hepatocyte nuclear factor 6 |
UniProt Synonym Protein Names: | One cut domain family member 1; One cut homeobox 1 |
UniProt Gene Name: | ONECUT1 |
UniProt Entry Name: | HNF6_HUMAN |
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