Anti-OGN Antibody (CAB6679)
- SKU:
- CAB6679
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-OGN Antibody |
| 抗体コード: | CAB6679 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-298 of human OGN (NP_148935.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | NIH/3T3, Mouse heart, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-298 of human OGN (NP_148935.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | APPT QQDS RIIY DYGT DNFE ESIF SQDY EDKY LDGK NIKE KETV IIPN EKSL QLQK DEAI TPLP PKKE NDEM PTCL LCVC LSGS VYCE EVDI DAVP PLPK ESAY LYAR FNKI KKLT AKDF ADIP NLRR LDFT GNLI EDIE DGTF SKLS LLEE LSLA ENQL LKLP VLPP KLTL FNAK YNKI KSRG IKAN AFKK LNNL TFLY LDHN ALES VPLN LPES LRVI HLQF NNIA SITD DTFC KAND TSYI RDRI EEIR LEGN PIVL GKHP NSFI CLKR LPIG SYF |
| 遺伝子ID: | 4969 |
| Uniprot: | P20774 |
| セルラーロケーション: | Secreted, extracellular matrix, extracellular space |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 36kDa |
| 同義語: | OGN, OG, OIF, SLRR3A, mimecan |
| バックグラウンド: | This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | OGN: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 9q22 Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; proteinaceous extracellular matrix; Golgi lumen; extracellular region; vesicle Molecular Function:protein binding; growth factor activity Biological Process: keratan sulfate metabolic process; glycosaminoglycan metabolic process; negative regulation of smooth muscle cell proliferation; keratan sulfate biosynthetic process; carbohydrate metabolic process; pathogenesis; keratan sulfate catabolic process |
| NCBI Summary: | This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P20774 |
| NCBI GenInfo Identifier: | 129078 |
| NCBI Gene ID: | 4969 |
| NCBI Accession: | P20774.1 |
| UniProt Related Accession: | P20774 |
| Molecular Weight: | |
| NCBI Full Name: | Mimecan |
| NCBI Synonym Full Names: | osteoglycin |
| NCBI Official Symbol: | OGN |
| NCBI Official Synonym Symbols: | OG; OIF; SLRR3A |
| NCBI Protein Information: | mimecan |
| UniProt Protein Name: | Mimecan |
| UniProt Synonym Protein Names: | Osteoglycin; Osteoinductive factor; OIF |
| Protein Family: | Mimecan |
| UniProt Gene Name: | OGN |
| UniProt Entry Name: | MIME_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OGN antibody (CAB6679) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using OGN antibody (CAB6679) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using OGN antibody (CAB6679) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U-2 OS cells using OGN antibody (CAB6679) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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