Anti-OCRL Antibody (CAB9290)
- SKU:
- CAB9290
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-OCRL Antibody |
| 抗体コード: | CAB9290 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human OCRL (NP_001578.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, A-549, 22Rv1, Mouse brain, Mouse lung, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human OCRL (NP_001578.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEPP LPVG AQPL ATVE GMEM KGPL REPC ALTL AQRN GQYE LIIQ LHEK EQHV QDII PINS HFRC VQEA EETL LIDI ASNS GCKI RVQG DWIR ERRF EIPD EEHC LKFL SAVL AAQK AQSQ LLVP EQKD SSSW YQKL DTKD KPSV FSGL LGFE DNFS SMNL DKKI NSQN QPTG IHRE PPPP PFSV NKML PREK EASN KEQP KVTN TMRK LFVP NTQS GQRE |
| 遺伝子ID: | 4952 |
| Uniprot: | Q01968 |
| セルラーロケーション: | Cell projection, Cytoplasmic vesicle, Early endosome membrane, Endosome, Golgi apparatus, Membrane, cilium, clathrin-coated pit, phagosome membrane, photoreceptor outer segment, trans-Golgi network |
| 計算された分子量: | 103kDa/104kDa |
| 観察された分子量: | 110kDa |
| 同義語: | OCRL, INPP5F, LOCR, NPHL2, OCRL-1, OCRL1 |
| バックグラウンド: | This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate (PubMed:25869668, PubMed:7761412, PubMed:9430698). May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). |
| NCBI Summary: | This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q01968 |
| NCBI GenInfo Identifier: | 13325072 |
| NCBI Gene ID: | 4952 |
| NCBI Accession: | NP_000267.2 |
| UniProt Related Accession: | Q01968 |
| Molecular Weight: | |
| NCBI Full Name: | inositol polyphosphate 5-phosphatase OCRL isoform a |
| NCBI Synonym Full Names: | OCRL inositol polyphosphate-5-phosphatase |
| NCBI Official Symbol: | OCRL |
| NCBI Official Synonym Symbols: | LOCR; NPHL2; OCRL1; Dent-2; INPP5F; OCRL-1 |
| NCBI Protein Information: | inositol polyphosphate 5-phosphatase OCRL |
| UniProt Protein Name: | Inositol polyphosphate 5-phosphatase OCRL-1 |
| UniProt Synonym Protein Names: | Lowe oculocerebrorenal syndrome protein |
| Protein Family: | Inositol polyphosphate 5-phosphatase |
| UniProt Gene Name: | OCRL |
 | Western blot analysis of extracts of various cell lines, using OCRL antibody (CAB9290) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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