Anti-NXN Antibody (CAB17206)
- SKU:
- CAB17206
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-NXN Antibody |
| 抗体コード: | CAB17206 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human NXN (NP_001192248.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human NXN (NP_001192248.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CRSL TRVL VESY RKIK EAGQ NFEI IFVS ADRS EESF KQYF SEMP WLAV PYTD EARR SRLN RLYG IQGI PTLI MLDP QGEV ITRQ GRVE VLND EDCR EFPW HPKP VLEL SDSN AAQL NEGP CLVL FVDS EDDG ESEA AKQL IQPI AEKI IAKY KAKE EEAP LLFF VAGE DDMT DSLR DYTN L |
| 遺伝子ID: | 64359 |
| Uniprot: | Q6DKJ4 |
| セルラーロケーション: | |
| 計算された分子量: | 20kDa/36kDa/48kDa |
| 観察された分子量: | 48kDa |
 | Western blot - NXN Rabbit pAb (CAB17206) |
| 同義語: | NXN, NRX, TRG-4 |
| バックグラウンド: | This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. |
| UniProt Protein Function: | NXN: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). Belongs to the nucleoredoxin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.8.1.8; Oxidoreductase Chromosomal Location of Human Ortholog: 17p13.3 Biological Process: negative regulation of protein ubiquitination; negative regulation of Wnt receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q6DKJ4 |
| NCBI GenInfo Identifier: | 187471109 |
| NCBI Gene ID: | 64359 |
| NCBI Accession: | Q6DKJ4.2 |
| UniProt Secondary Accession: | Q6DKJ4,Q3SWW6, Q6P3U6, Q7L4C6, Q9H9Q1, B4DXQ0, D3DTH2 |
| UniProt Related Accession: | Q6DKJ4 |
| Molecular Weight: | 36,871 Da |
| NCBI Full Name: | Nucleoredoxin |
| NCBI Synonym Full Names: | nucleoredoxin |
| NCBI Official Symbol: | NXN |
| NCBI Official Synonym Symbols: | NRX; TRG-4 |
| NCBI Protein Information: | nucleoredoxin |
| UniProt Protein Name: | Nucleoredoxin |
| Protein Family: | Nucleoredoxin |
| UniProt Gene Name: | NXN |
| UniProt Entry Name: | NXN_HUMAN |