Anti-NXF1 Antibody (CAB5907)
- SKU:
- CAB5907
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-NXF1 Antibody |
| 抗体コード: | CAB5907 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 57-356 of human NXF1 (NP_001074960.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | 293T, HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 57-356 of human NXF1 (NP_001074960.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GDVA MSDA QDGP RVRY NPYT TRPN RRGD TWHD RDRI HVTV RRDR APPE RGGA GTSQ DGTS KNWF KITI PYGR KYDK AWLL SMIQ SKCS VPFT PIEF HYEN TRAQ FFVE DAST ASAL KAVN YKIL DREN RRIS IIIN SSAP PHTI LNEL KPEQ VEQL KLIM SKRY DGSQ QALD LKGL RSDP DLVA QNID VVLN RRSC MAAT LRII EENI PELL SLNL SNNR LYRL DDMS SIVQ KAPN LKIL NLSG NELK SERE LDKI KGLK LEEL WLDG NSLC DTFR DQST YIRS VVAC VSPP GDLH PLGG |
| 遺伝子ID: | 10482 |
| Uniprot: | Q9UBU9 |
| セルラーロケーション: | Cytoplasm, Nucleus, Nucleus speckle, nucleoplasm |
| 計算された分子量: | 40kDa/70kDa |
| 観察された分子量: | 70kDa |
| 同義語: | NXF1, MEX67, TAP |
| バックグラウンド: | This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. |
| NCBI Summary: | This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBU9 |
| NCBI GenInfo Identifier: | 20139282 |
| NCBI Gene ID: | 10482 |
| NCBI Accession: | Q9UBU9.1 |
| UniProt Secondary Accession: | Q9UBU9,Q99799, Q9UQL2, B4E269, |
| UniProt Related Accession: | Q9UBU9 |
| Molecular Weight: | 40,476 Da |
| NCBI Full Name: | Nuclear RNA export factor 1 |
| NCBI Synonym Full Names: | nuclear RNA export factor 1 |
| NCBI Official Symbol: | NXF1 |
| NCBI Official Synonym Symbols: | TAP; MEX67 |
| NCBI Protein Information: | nuclear RNA export factor 1 |
| UniProt Protein Name: | Nuclear RNA export factor 1 |
| UniProt Synonym Protein Names: | Tip-associated protein; Tip-associating protein; mRNA export factor TAP |
| Protein Family: | Nuclear RNA export factor |
| UniProt Gene Name: | NXF1 |
| UniProt Entry Name: | NXF1_HUMAN |
 | Western blot - NXF1 Polyclonal Antibody (CAB5907) |
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