Anti-NUDT5 Antibody (CAB10493)
- SKU:
- CAB10493
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-NUDT5 Antibody |
| 抗体コード: | CAB10493 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-219 of human NUDT5 (NP_054861.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, LO2, DU145, HT-1080, Mouse liver, Mouse kidney, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-219 of human NUDT5 (NP_054861.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MESQ EPTE SSQN GKQY IISE ELIS EGKW VKLE KTTY MDPT GKTR TWES VKRT TRKE QTAD GVAV IPVL QRTL HYEC IVLV KQFR PPMG GYCI EFPA GLID DGET PEAA ALRE LEEE TGYK GDIA ECSP AVCM DPGL SNCT IHIV TVTI NGDD AENA RPKP KPGD GEFV EVIS LPKN DLLQ RLDA LVAE EHLT VDAR VYSY ALAL KHAN AKPF EVPF LKF |
| 遺伝子ID: | 11164 |
| Uniprot: | Q9UKK9 |
| セルラーロケーション: | |
| 計算された分子量: | 24kDa |
| 観察された分子量: | 36kDa |
| 同義語: | NUDT5, YSA1, YSA1H, YSAH1, hNUDT5 |
| バックグラウンド: | This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. |
| UniProt Protein Function: | NUDT5: Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Belongs to the Nudix hydrolase family. |
| UniProt Protein Details: | Protein type:EC 3.6.1.13; EC 3.6.1.58; Nucleotide Metabolism - purine; Phosphatase Chromosomal Location of Human Ortholog: 10p14 Cellular Component: cytosol; nucleus Molecular Function:ADP-ribose diphosphatase activity; ADP-sugar diphosphatase activity; m7G(5')pppN diphosphatase activity; magnesium ion binding; nucleotidyltransferase activity; protein binding; protein homodimerization activity; snoRNA binding Biological Process: chromatin remodeling; D-ribose catabolic process; ribonucleoside diphosphate catabolic process |
| NCBI Summary: | This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9UKK9 |
| NCBI GenInfo Identifier: | 20455192 |
| NCBI Gene ID: | 11164 |
| NCBI Accession: | Q9UKK9.1 |
| UniProt Secondary Accession: | Q9UKK9,Q6IAG0, Q9UH49, A8K516, |
| UniProt Related Accession: | Q9UKK9 |
| Molecular Weight: | 24kDa |
| NCBI Full Name: | ADP-sugar pyrophosphatase |
| NCBI Synonym Full Names: | nudix hydrolase 5 |
| NCBI Official Symbol: | NUDT5 |
| NCBI Official Synonym Symbols: | YSA1; YSA1H; YSAH1; hNUDT5 |
| NCBI Protein Information: | ADP-sugar pyrophosphatase |
| UniProt Protein Name: | ADP-sugar pyrophosphatase |
| UniProt Synonym Protein Names: | 8-oxo-dGDP phosphatase (EC:3.6.1.58 |
| Protein Family: | Nudix hydrolase |
| UniProt Gene Name: | NUDT5 |
 | Western blot analysis of extracts of various cell lines, using NUDT5 antibody (CAB10493) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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